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Sodium cefamandole

Sodium cefamandole Basic information
Product Name:Sodium cefamandole
Synonyms:(6R,7R)-7-[[(2R)-2-Hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt;CEFAMANDOLE SODIUM;CEFAMANDOLE SODIUM SALT;5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-mandelamido-3-(((1-met;monosodiumsalt,d-hyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo;(6R,7R)-7-[(R)-2-Hydroxy-2-phenylacetylamino]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt;Cephamandole sodium;Cefamandole Sodium (250 mg)
CAS:30034-03-8
MF:C18H17N6NaO5S2
MW:484.48
EINECS:250-009-0
Product Categories:A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Spectrum of Activity;Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:30034-03-8.mol
Sodium cefamandole Structure
Sodium cefamandole Chemical Properties
Melting point >175°C (dec.)
storage temp. Store at RT.
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form Solid
color White to Pale Yellow
Stability:Moisture Sensitive
CAS DataBase Reference30034-03-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 36/37/38-42/43
Safety Statements 26-36
WGK Germany 2
RTECS XI0389000
Toxicitymouse,LD50,intravenous,4460mg/kg (4460mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984.
MSDS Information
Sodium cefamandole Usage And Synthesis
DescriptionCefamandole is a cephalosporin antibiotic that is effective against E. coli (MIC values range from 0.25-2 mg/L depending on strain) as well as H. influenza, S. pneumoniae, and S. aureus. It has been used to study the expression and inhibition of penicillin-binding proteins on bacterial cell walls and to study antibiotic resistance.
Chemical PropertiesWhite Solid
UsesAntibacterial;Bacterial transpeptidase inhibitor
UsesBroad-spectrum semi-synthetic cephalosporin antibiotic.
DefinitionChEBI: An organic sodium salt that is the sodium salt of cefamandole.
in vitrothe in-vitro effect of cefamandole was tested against 645 strains of bacteria isolated from clinical sources. against gram-positive organisms cefamandole showed great potency, being three- to four-fold more active than cephalexin or cefoxitin. none of the pseudomonas aeruginosa strains were susceptible to 100 μg of cefamandole per ml [1].
in vivothe testicular toxicity of cefamandole was evaluated in neonatal rats. results showed that cefamandole caused delayed maturity of the germinal epithelium of neonatal rats. in rats given daily subcutaneous injections during this period, the most mature germinal cells were acrosome phase spermatids [2].
references[1] eickhoff tc, ehret jm. in vitro comparison of cefoxitin, cefamandole, cephalexin, and cephalothin. antimicrob agents chemother. 1976 jun;9(6):994-9.
[2] hoover dm, buening mk, tamura rn, steinberger e. effects of cefamandole on spermatogenic development of young cd rats. fundam appl toxicol. 1989 nov;13(4):737-46.
[3] delgado dg, brau cj, cobbs cg, dismukes we. clinical and laboratory evaluation of cefamandole in the therapy of haemophilus spp. bronchopulmonary infections. antimicrob agents chemother. 1979 jun;15(6):807-12.
Sodium cefamandole Preparation Products And Raw materials
Sodium benzoate Sodium acetate 1H-TETRAZOLE Acetaminophen ACETAMINOPHENOL BP/USP Cefamandole sodium Sodium cefamandole Sodium chloride Cefonicid Cemandil sodium salt Diclofenac sodium Sodium formate Sodium bicarbonate Sodium hydroxide 7-TMCA(inter.for cefamandole sodium,cefoperazone,cefpiramide) Sodium gluconate
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