2-Amino-3-benzyloxypyridine

2-Amino-3-benzyloxypyridine Basic information

Product Name:	2-Amino-3-benzyloxypyridine
Synonyms:	TIMTEC-BB SBB000394;3-(Benzyloxy)pyridin-2-amine, 2-Aminopyridin-3-yl benzyl ether;2-AMino-3-benzyloxypyridine, 98.5% 5GR;2-Amino-3-benzyloxypyridine ,99%;2-Amino-3-benzyloxyp;2-amino-3-(phenylmethoxy)pyridine;2-Amino-3-benzyloxypyridine, 98.5%;NSC 298538
CAS:	24016-03-3
MF:	C12H12N2O
MW:	200.24
EINECS:	245-983-9
Product Categories:	Amines;Aromatics;Heterocycles;A-AM;Bioactive Small Molecules;Building Blocks;Pyridines;Bases & Related Reagents;C9 to C46;Heterocyclic Building Blocks;C12;Cell Biology;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines, Pyrimidines, Purines and Pteredines;Heterocyclic Series;Pyridine;Pyridines derivates;Nucleotides and Nucleosides;Nucleotides
Mol File:	24016-03-3.mol

2-Amino-3-benzyloxypyridine Chemical Properties

Melting point	92-94 °C (lit.)
Boiling point	337.96°C (rough estimate)
density	1.1131 (rough estimate)
refractive index	1.6660 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Crystalline Powder
pka	8.40±0.10(Predicted)
color	Green to brown
BRN	392674
CAS DataBase Reference	24016-03-3(CAS DataBase Reference)
NIST Chemistry Reference	2-Pyridinamine, 3-(phenylmethoxy)-(24016-03-3)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22
Safety Statements	26-37/39-24/25-36/37/39-22,26-36
RIDADR	UN2811
WGK Germany	3
Hazard Note	Irritant
HS Code	29221985

MSDS Information

Provider	Language
3-Benzyloxy-2-pyridylamine	English
ACROS	English
SigmaAldrich	English
ALFA	English

2-Amino-3-benzyloxypyridine Usage And Synthesis

Chemical Properties	Brown crystalline powder
Uses	2-Amino-3-benzyloxypyridine is used in preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors.
Uses	2-Amino-3-benzyloxypyridine was used in the synthesis of 1-acetyl-2-[2-(3-benzyloxypyridinyl)]iminoimidazolidine.
General Description	2-Amino-3-benzyloxypyridine on condensation with diethyl ethoxymethylene malonate affords 9-benzyloxy-3-ethoxycarbonylpyrido[1,2-a]pyrimidin-4-one.
Biochem/physiol Actions	2-Amino-3-benzyloxypyridine is an inhibitor of mitogen-activated protein kinase p38α activity.

2-Amino-3-benzyloxypyridine Preparation Products And Raw materials

Raw materials	2-Amino-3-hydroxypyridine-->Benzyl chloride-->Benzyl bromide
Preparation Products	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one-->8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-->8-BENZYLOXY-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER-->[1,2,4]Triazolo[1,5-a]pyridin-2-amine, 8-(phenylmethoxy)-

1-PHENYL-3-(3-(PHENYLMETHOXY)(2-PYRIDYL))UREA 2-CHLORO-N-(3-[(2,5-DIMETHYLBENZYL)OXY]-6-METHYLPYRIDIN-2-YL)ACETAMIDE N-(3-(BENZYLOXY)(2-PYRIDYL))-2-THIENYLFORMAMIDE (3-(PHENYLMETHOXY)(2-PYRIDYL))((4-(TRIFLUOROMETHOXY)PHENYL)SULFONYL)AMINE 4-Methoxybenzylchloride 1-(4-NITROPHENYL)-3-(3-(PHENYLMETHOXY)(2-PYRIDYL))UREA 2-Amino-3-benzyloxypyridine 1-(CYCLOHEXYL)-3-(3-(PHENYLMETHOXY)(2-PYRIDYL))UREA 1-(4-CHLOROBENZOYL)-3-(3-(BENZYLOXY)(2-PYRIDYL))THIOUREA 3-[(3,4-DICHLOROBENZYL)OXY]PYRIDIN-2-AMINE 1-(3-TRIFLUOROMETHYLPHENYL)-3-(3-BENZYLOXY(2-PYRIDYL))UREA Tris(hydroxymethyl)aminomethane N-(4-(((3-(PHENYLMETHOXY)-2-PYRIDYL)AMINO)SULFONYL)PHENYL)ETHANAMIDE 3-PHENYL-N-(3-(PHENYLMETHOXY)(2-PYRIDYL))PROP-2-ENAMIDE 3-[(3-methylphenyl)methoxy]pyridin-2-amine 3-[(4-methoxyphenyl)methoxy]pyridin-2-amine 3-[(2,5-DIMETHYLBENZYL)OXY]-6-METHYLPYRIDIN-2-AMINE 4-Dimethylaminopyridine

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