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| Tetrahydro-4H-pyran-4-one Chemical Properties |
Boiling point | 166-166.5 °C (lit.) | density | 1.084 g/mL at 25 °C (lit.) | refractive index | n20/D 1.452(lit.) | Fp | 134 °F | storage temp. | Inert atmosphere,Room Temperature | form | Liquid | color | Clear colorless to pale yellow | Water Solubility | MISCIBLE | BRN | 106463 | InChIKey | JMJRYTGVHCAYCT-UHFFFAOYSA-N | CAS DataBase Reference | 29943-42-8(CAS DataBase Reference) | NIST Chemistry Reference | 4H-Pyran-4-one, tetrahydro-(29943-42-8) |
Hazard Codes | Xi,F | Risk Statements | 10-36/37/38 | Safety Statements | 24/25-36-26 | RIDADR | UN 1224 3/PG 3 | WGK Germany | 3 | F | 10 | Hazard Note | Keep Cold/Flammable/Irritant | HazardClass | 3.2 | PackingGroup | III | HS Code | 29329995 |
| Tetrahydro-4H-pyran-4-one Usage And Synthesis |
Description | Tetrahydro-4H-pyran-4-one is used in organic synthesis as building block for more complex chemical structures because it participate in a variety of cycloaddition reactions. Tetrahydro-4H-pyran-4-one is employed in the preparation of 4-methoxytetrahydropyran-4-yl protecting group, synthesis of symmetric tetra substituted methanes. The methyl enol ether is a useful protecting agent for alcohols, e.g. in nucleotide synthesis, with the advantage over 3,4-Dihydro-2H-pyran. Tetrahydro-4H-pyran-4-one is also employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid. It undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. Tetrahydro-4H-pyran-4-one is also employed in wittig reactions for the synthesis of Penicillins and in a ring of vitamin D3. | Application | Tetrahydro-4-pyrone is used in organic synthesis as a building block for more complex chemical structures because it participates in a variety of cycloaddition reactions. Tetrahydro-4H-pyran-4-one is employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid and it undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. Tetrahydro-4H-pyran-4-one is also employed in wittig reactions for the synthesis of penicillins and in a ring of vitamin D3. Additionally, tetrahydro-4-pyrone is used as solvents in some reactions.
| Chemical Properties | colorless to light yellow liquid | Uses | Tetrahydro-4-pyrone is used in organic synthesis as building block for more complex chemical structures because it participate in a variety of cycloaddition reactions. | Purification Methods | Purify the pyrone by repeated distillation, preferably in a vacuum. [Baker J Chem Soc 296 1944, IR: Olsen & Bredoch Chem Ber 91 1589 1958.] The oxime has m 87-88o and b 110-111o/13mm [Cornubert et al. Bull Soc Chim Fr 36 1950]. The 4-nitrophenylhydrazone forms orange-brown needles from EtOH, m 186o [Cawley & Plant J Chem Soc 1214 1938]. [Beilstein 17 I 131, 17 II 287, 17 III/IV 4171, 17/9 V 21.] |
| Tetrahydro-4H-pyran-4-one Preparation Products And Raw materials |
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