|
| | ROBISON ESTER MONOSODIUM SALT Basic information |
| | ROBISON ESTER MONOSODIUM SALT Chemical Properties |
| Melting point | 204 °C (dec.)(lit.) | | storage temp. | Sealed in dry,Room Temperature | | solubility | H2O: 50 mg/mL, clear, colorless to very faintly yellow | | form | crystalline | | BRN | 5787568 | | CAS DataBase Reference | 54010-71-8(CAS DataBase Reference) |
| | ROBISON ESTER MONOSODIUM SALT Usage And Synthesis |
| Description | D-Glucose-6-phosphate is formed in cells when glucose is phosphorylated by hexokinase (or glucokinase) or by the conversion of glucose-1-phosphate by phosphoglucomutase, which is the first step of glycogen synthesis. It is stored as glycogen when blood glucose levels are high. Disruption of D-glucose-6-phosphate activity leads to glycogen storage disease type I or von Gierke’s disease, a group of inherited metabolic diseases characterized by severe hypoglycemia, growth retardation, and hepatomegaly, due to accumulation of glycogen and fat in the liver. D-Glucose-6-phosphate is also the starting molecule of both glycolysis and the pentose phosphate pathways. Because cancer cells adopt glycolysis as a major source of metabolic energy production, and the pentose phosphate pathway plays a role in helping glycolytic cancer cells to meet their anabolic demands, this compound can be used to study the progression of this process. | | Chemical Properties | White crystalline solid | | General Description | A glycolytic intermediate that also acts as a competitive and reversible inhibitor of hexokinase. Useful in creating an ATP-regenerating system. Causes the release of mitochondrially bound hexokinase in muscle. | | Purification Methods | It can be freed from metal impurities as described for glucose-1-phosphate. The solubility of the Na salt is 5% in H2O at 20o. Its barium salt can be purified by solution in dilute HCl and precipitation by neutralising the solution. The precipitate is washed with small volumes of cold water and dried in air. Alternatively the barium salt is dissolved in H2O, 4volumes of EtOH are added, the precipitate is collected, washed with 90% EtOH, absolute EtOH, 75% EtOH/25% Et2O, 25% EtOH/75% Et2O and finally dry Et2O. The dry Barium salt has [] D +17.9o (c 1, H2O). [Beilstein 1 IV.] |
| | ROBISON ESTER MONOSODIUM SALT Preparation Products And Raw materials |
|
