NU 6027

NU 6027 Basic information
Product Name:NU 6027
Synonyms:ATR/CDK Inhibitor, NU6027 - CAS 220036-08-8 - Calbiochem;NU6027;NU-6027;NU 6027;2,4-Pyrimidinediamine, 6-(cyclohexylmethoxy)-5-nitroso-;ATR/CDK Inhibitor, NU6027;2,6-DiaMino-4-(cyclohexylMethoxy)-5-nitrosopyriMidine;6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine;NU 6027 USP/EP/BP;inhibit,Ataxia telangiectasia mutated,Cyclin dependent kinase,ATM/ATR,NU 6027,cytotoxicity,NU6027,Inhibitor,NU-6027,CDK2,cisplatin,hydroxyurea,ATR,CDK1,CDK,ATM and RAD3 related,cancer
CAS:220036-08-8
MF:C11H17N5O2
MW:251.29
EINECS:
Product Categories:Inhibitors
Mol File:220036-08-8.mol
NU 6027 Structure
NU 6027 Chemical Properties
Melting point 252.5-253.7 °C(lit.)
Boiling point 549.2±60.0 °C(Predicted)
density 1.53±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 15 mg/mL
pka2.52±0.10(Predicted)
form Reddish-purple powder
color lavender
Safety Information
WGK Germany 3
MSDS Information
NU 6027 Usage And Synthesis
UsesNU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors
targetCDK1
NU 6027 Preparation Products And Raw materials
SU 9516

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