Palbociclib-012

Palbociclib-012 Basic information
Product Name:Palbociclib-012
Synonyms:Palbociclib-012;Palbociclib impurity 15/di-tert-butyl 4,4'-(((8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2,6-diyl)bis(azanediyl))bis(pyridine-6,3-diyl))bis(piperazine-1-carboxylate);di-tert-butyl 4,4'-(((8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2,6-diyl)bis(azanediyl))bis(pyridine-6,3-diyl))bis(piperazine-1-carboxylate);di-tert-Butyl 4,4'-(6,6'-((8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2,6-diyl)bis(azanediyl))bis(pyridine-6,3-diyl))bis(piperazine-1-carboxylate);"di-tert-Butyl 4,4-(6,6-((8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2,6-diyl)bis(azanediyl))bis(pyridine-6,3-diyl))bis(piperazine-1-carboxylate)"Q: What is "di-tert-Butyl 4,4-(6,6-((8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2,6-diyl)bis(azanediyl))bis(pyridine-6,3-diyl))bis(piperazine-1-carboxylate)" Q: What is the CAS Number of "di-tert-Butyl 4,4-(6,6-((8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2,6-diyl)bis(azanediyl))bis(pyridine-6,3-diyl))bis(piperazine-1-carboxylate)";Xylulose-13C1A
CAS:2206135-30-8
MF:C41H55N11O5
MW:781.96
EINECS:
Product Categories:
Mol File:2206135-30-8.mol
Palbociclib-012 Structure
Palbociclib-012 Chemical Properties
Boiling point 918.6±75.0 °C(Predicted)
density 1.302±0.06 g/cm3(Predicted)
pka6.28±0.10(Predicted)
Safety Information
MSDS Information
Palbociclib-012 Usage And Synthesis
Usesdi-tert-Butyl 4,4''-(6,6''-((8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2,6-diyl)bis(azanediyl))bis(pyridine-6,3-diyl))bis(piperazine-1-carboxylate) is an impurity of Palbociclib (P139900) an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
Palbociclib-012 Preparation Products And Raw materials
6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one 5-bromo-4-chloro-N-cyclopentylpyrimidin-2-amine PalBociclib Impurity 22 PD 0332991 HCl 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 5-(piperazin-1-yl)pyridin-2-aMine 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Palbociclib-030 Phosphine oxide, tris (2-methylphenyl)- Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]- 8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-6-vinylpyrido[2,3-d]pyrimidin-7(8H)-one Palbociclib-029 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Palbociclib tert-Butyl 4-(2-nitropyridin-3-yl)piperazine-1-carboxylate Palbociclib-007 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

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