2,3,5,6-Tetrafluoropyridine

2,3,5,6-Tetrafluoropyridine Basic information
Synthesis Preparation Description
Product Name:2,3,5,6-Tetrafluoropyridine
Synonyms:2,3,5,6-TETRAFLUOROPYRIDINE;2,3,5,6-Tetrafluoropyridine 98%;2,3,5,6-Tetrafluoropyridine98%;2,3,5,6-Tetrafluoropyridine,99%;N-TERT-BUTYL-ALPHA-(4-NITROPHENYL)- &;Pyridine,2,3,5,6-tetrafluoro-;2,3,5,6-TetrafL;2,3,5,6-Tetrafluoropyridine ISO 9001:2015 REACH
CAS:2875-18-5
MF:C5HF4N
MW:151.06
EINECS:622-979-9
Product Categories:Fluorine series;Pyridine;Heterocyclic Compounds;Fluoropyridines;Halopyridines;C5;Heterocyclic Building Blocks;Pyridines
Mol File:2875-18-5.mol
2,3,5,6-Tetrafluoropyridine Structure
2,3,5,6-Tetrafluoropyridine Chemical Properties
Boiling point 102 °C (lit.)
density 1.499 g/mL at 25 °C (lit.)
refractive index n20/D 1.4046(lit.)
Fp 87 °F
storage temp. Inert atmosphere,2-8°C
pka-10.94±0.20(Predicted)
form clear liquid
Specific Gravity1.52
color Colorless to Light yellow
InChIKeyHWIPMBCMGVXOKN-UHFFFAOYSA-N
CAS DataBase Reference2875-18-5(CAS DataBase Reference)
NIST Chemistry ReferencePyridine, 2,3,5,6-tetrafluoro-(2875-18-5)
Safety Information
Hazard Codes Xi,F,C
Risk Statements 10-36/37/38
Safety Statements 28-36
RIDADR UN 1993 3/PG 3
WGK Germany 3
Hazard Note Flammable/Irritant
HazardClass 3
PackingGroup III
HS Code 29333990
MSDS Information
ProviderLanguage
2,3,5,6-Tetrafluoropyridine English
SigmaAldrich English
ALFA English
2,3,5,6-Tetrafluoropyridine Usage And Synthesis
SynthesisCatalytic reduction of aryl chlorides, bromides and iodides is well documented, however, aryl fluorides do not readily react under these conditions, owing to the strong C-F bond and the high activation barrier to bond breaking. Work in our laboratories showed that at high temperatures, pentafluoropyridine was converted to 2,3,5,6- tetrafluoropyridine using a palladium catalyst.
	2,3,5,6-Tetrafluoropyridine
PreparationAn autoclave sprayed with PTFE was charged with pentafluoropyridine (20.0 g,  118 mmol), HBr (32.0 g, 400 mmol) and sulpholane (40 cm3) and heated at 200 ℃ for  48 h. The mixture was added to water and extracted into ether. The ether solution was  shown to contain pentafluoropyridine (79%) and 2,3,5,6-tetrafluoropyridine (21%) by  comparison of their GCMS and fluorine nmr spectra with authentic samples.  
Description

Pyridine and its derivatives have been developed and utilized relatively early at home and abroad. It is widely used in medicine, pesticides, rubber, dyes and other fields. Since the 1960s, there have been hundreds of medicines, pesticides, dyes, and some special reagents developed with fluorine-containing aromatic compounds as intermediates. In the weakly basic pyridine ring, the nitrogen atom is more negatively charged, and then a fluorine atom with a strong electronegativity is introduced to synthesize a fluorine-containing pyridine intermediate.

Chemical Propertiesclear colorless liquid
(2,3,5,6-TETRAFLUORO-4-PYRIDINYL)ACETIC ACID RARECHEM AL BW 1450 Pentafluoropyridine 4-HYDRAZINO-2,3,5,6-TETRAFLUOROPYRIDINE 2,3,5,6-Tetrafluoropyridine 2,3,5,6-TETRAFLUOROPYRIDINE-4-CARBOXYLIC ACID Dimefluthrin 4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-{[2-(TRIFLUOROMETHYL)PHENYL]SULFONYL}PIPERAZINE-1-CARBOXAMIDE N-[(3,5-DICHLOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE 2,3,5,6-TETRAFLUORO-ISONICOTINAMIDINE 2,3,5,6-TETRAFLUORO-4-NITROPYRIDINE N-[(4-FLUOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE N-[(3,4-DICHLOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE 4-HYDROXY-2,3,5,6-TETRAFLUOROPYRIDINE 4-BROMO-2,3,5,6-TETRAFLUOROPYRIDINE,4-BROMO-2,3,5,6-TETRAFLUOROPYRIDINE 98% 1,1,1,2-Tetrafluoroethane Polytetrafluorethylene wire rod 4-Methyl-2,3,5,6-tetrafluoropyridine 99%+

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