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| | 4-Bromobenzonitrile Basic information |
| | 4-Bromobenzonitrile Chemical Properties |
| Melting point | 110-115 °C(lit.) | | Boiling point | 235-237 °C(lit.) | | density | 1,562 g/cm3 | | refractive index | 1.5999 (estimate) | | Fp | 130°C | | storage temp. | Sealed in dry,Room Temperature | | solubility | 0.2g/l | | form | Powder or Flakes | | color | White to light yellow or flakes | | Water Solubility | Very slightly soluble in water(0.2g/L). Soluble in alcohol and ether. | | BRN | 2041518 | | InChIKey | HQSCPPCMBMFJJN-UHFFFAOYSA-N | | LogP | 2.3 at 22.5℃ and pH7 | | CAS DataBase Reference | 623-00-7(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Bromobenzoic acid nitrile(623-00-7) |
| | 4-Bromobenzonitrile Usage And Synthesis |
| Chemical Properties | 4-Bromobenzonitrile is white to light yellow powder or flakes
| | Uses | 4-Bromobenzonitrile is used as reagents and solvents. Reaction of 2-propanol, 4-bromobenzonitrile, and NaH in the presence of 1.5 mol % Pd2(dba)3 and 3 mol % (S)-(-)2,2?-bis(di-p-tolylphosphino)- 1,1?-binaphthyl at 50°C afforded 4-isopropoxy- benzonitrile in 80% isolated yield. The synthesis of 4-cyanobiphenyl at room temperature in a flow injection microreactor, using a supported catalyst, without the addition of a base gave a product yield of 67±7% (n=6). This was achieved by injecting 4-bromobenzonitrile. The 3-arylation of 2,5-dimethylthiophene with 4-bromopropiophenone, 4-trifluoromethylbromobenzene or 4-bromobenzonitrile gave 3-5 in only 38-50% yields in Palladium-catalysed direct 3-or 4-arylation of thiophene derivatives using aryl bromides. | | Uses | 4- Bromobenzonitrile is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceu
ticals and other organic chemicals, | | Synthesis Reference(s) | Tetrahedron Letters, 27, p. 1925, 1986 DOI: 10.1016/S0040-4039(00)84413-5 |
| | 4-Bromobenzonitrile Preparation Products And Raw materials |
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