Sodium acetate trihydrate

Sodium acetate trihydrate Basic information

Product Name:	Sodium acetate trihydrate
Synonyms:	Acetic acid, sodium salt trihydrate, for analysis;Acetic acid, sodium salt trihydrate, for analysis ACS;Acetic acid sodium trihydrate;Acetic acid sodium·trihydrate;Sodium Acetate Trihydrate, Acs-100.5%;Acetic acid, sodium salt trihydrate, for analysis ACS, 99+%;SodiuM Acetate (AS);SodiuM Acetate, Trihydrate, HPLC Grade
CAS:	6131-90-4
MF:	C2H9NaO5
MW:	136.08
EINECS:	612-115-9
Product Categories:	mordant dyes;Food additive;API;printing and dyeing;Organic chemistry;Food Additives;INORGANIC & ORGANIC CHEMICALS;Inorganic Chemicals;6131-90-4
Mol File:	6131-90-4.mol

Sodium acetate trihydrate Chemical Properties

Melting point	58 °C
Boiling point	>400°C
density	1,45 g/cm³
Fp	>250°C
storage temp.	Store at +5°C to +30°C.
solubility	H₂O: 3 M at 20 °C, clear, colorless
form	Solid
color	White
Odor	Slight acetic acid
PH	7.5-9.0 (25℃, 50mg/mL in H2O)
PH Range	8.5 - 10 at 408 g/l at 25 °C
pka	4.76 (acetic acid)(at 25℃)
Water Solubility	762 g/L (20 ºC)
λmax	λ: 260 nm Amax: ≤0.01 λ: 280 nm Amax: ≤0.01
Merck	14,8571
BRN	3732037
Stability:	Stable. Incompatible with strong oxidizing agents, halogens.
InChIKey	AYRVGWHSXIMRAB-UHFFFAOYSA-M
LogP	-0.285 (est)
CAS DataBase Reference	6131-90-4(CAS DataBase Reference)
NIST Chemistry Reference	Sodium acetate trihydrate(6131-90-4)
EPA Substance Registry System	Acetic acid, sodium salt, trihydrate (6131-90-4)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	24/25-36-26
WGK Germany	1
RTECS	AJ4580000
Autoignition Temperature	607 °C
TSCA	Yes
HS Code	29152200
Toxicity	LD50 orally in Rabbit: 3530 mg/kg LD50 dermal Rabbit > 10000 mg/kg

MSDS Information

Provider	Language
Acetic acid sodium salt trihydrate	English
SigmaAldrich	English
ACROS	English
ALFA	English

Sodium acetate trihydrate Usage And Synthesis

Chemical Properties	Sodium acetate trihydrate is the trihydrate sodium salt oaf acetic acid. It is a colorless, odorless crystals that can be weathered in the air. Soluble in water and ether, pH of 0.1M aqueous solution is 8.9. moderately soluble in ethanol, 5.3 g/100mL. Anhydrous Sodium acetate occurs as colorless, transparent crystals or a granular crystalline powder with a slight acetic acid odor.
Uses	Sodium acetate trihydrate is used in various applications. It is used as a buffer of a pH range in between to 4.0 to 6.0. It is also used in the purification and precipitation of nucleic acids and in protein crystallization. It is used as a mordant dyeing, as a pickling agent in chrome tanning, as a neutralizer in waste streams containing sulfuric acid, in the textile industry and as a photoresist while using aniline dyes. It plays an important role to retard vulcanization of chloroprene in synthetic rubber production. It is a precursor to prepare ester from alkyl halide. Other applications are in photography, as an additive to food, in purification of glucose, in preservation of meat, in tanning, and as a dehydrating agent. In analytical chemistry it is used to prepare buffer solution.
Preparation	Sodium acetate is prepared by reacting sodium hydroxide or sodium carbonate with acetic acid in aqueous solution. The solution is evaporated to obtain hydrated crystals of sodium acetate. NaOH + CH3COOH → CH3COONa + H2O Na2CO3 + CH3COOH → 2CH3COONa + CO2 + H2O
Definition	ChEBI: Sodium acetate trihydrate is a hydrate. It contains a sodium acetate.
General Description	Sodium acetate trihydrate can be obtained from the crystallization of sodium acetate in water. On heating at 75°C, it melts, while on heating above 120°C it loses water of crystallization and gets converted into anhydrous form. The hyperfine proton and ¹³C splittings have been evaluated by recording ESR spectra of its irradiated single crystals. ESR studies suggested the existence of trapped methyl radicals. Its crystals are monoclinic and its crystal structure has been investigated by photographic methods. Unit cell parameters were evaluated.
Pharmaceutical Applications	Sodium acetate is used as part of a buffer system when combined with acetic acid in various intramuscular, intravenous, topical, ophthalmic, nasal, oral, otic, and subcutaneous formulations. It may be used to reduce the bitterness of oral pharmaceuticals. It can be used to enhance the antimicrobial properties of formulations; it has been shown to inhibit the growth of S. aureus and E. coli, but not C. albicans in protein hydrolysate solutions. It is widely used in the food industry as a preservative. Sodium acetate has also been used therapeutically for the treatment of metabolic acidosis in premature infants, and in hemodialysis solutions.
Biochem/physiol Actions	Sodium acetate trihydrate (SAT) is a phase change material (PCM) that can be easily combined with the preparation of domestic hot water, space heating, solar heating, and radiant floor heating systems. The hydrated salt of SAT possesses high latent heat density and thus can be used for low-temperature heat storage.
Safety	Sodium acetate is widely used in cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. A short-term feeding study in chickens with a diet supplemented with 5.44% sodium acetate showed reduced growth rates that were attributed to the sodium content.(9) Sodium acetate is poisonous if injected intravenously, is moderately toxic by ingestion, and is an irritant to the skin and eyes. LD50 (rat, oral): 3.53 g/kg LD50 (mouse, IV): 0.38 g/kg LD50 (mouse, SC): 8.0 g/kg
storage	Sodium acetate should be stored in airtight containers.
Incompatibilities	Sodium acetate reacts with acidic and basic components. It will react violently with fluorine, potassium nitrate, and diketene.
Regulatory Status	GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections, nasal, otic, ophthalmic, and oral preparations).
References	[1] http://www.europlat.org [2] http://www.rxlist.com/sodium-acetate-drug.htm [3] http://cosmetics.specialchem.com [4] http://cecri.csircentral.net/2710/1/036-96.pdf

Sodium acetate trihydrate Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Acetic acid-->Sodium carbonate-->Activated carbon

Preparation Products

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE-->ISOXANTHOPTERIN-->Gardenia blue pigment-->Pigment Red 13-->5-Ethyl-2-thiophenecarboxaldehyde-->2-Acetyl pyrrole-->5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE-->3-(2-FURYL)ISOXAZOL-5-AMINE-->5-METHYL-4-ISOXAZOLECARBONYL CHLORIDE-->2-AMINO-4-(4-CHLORO-PHENYL)-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER-->6-AMINO-5-NITROSO-3-METHYLURACIL-->2,6-Dithiopurine-->Cefotaxime-->LEAD PHOSPHITE, DIBASIC-->3-Amino-5-phenylpyrazole-->Coumarin 30-->Pigment Red 175-->Cephalothin sodium-->Geranyl acetate-->6-HYDROXY-7-METHOXYCOUMARIN-->BISPYRAZOLONE-->VINYL STEARATE-->Pigment Red 32-->Sodium diacetate-->o-Anisic acid-->8-METHOXYCOUMARIN-->6-METHOXYCOUMARIN-->PALMITIC ACID VINYL ESTER-->3,3'-Dihydroxybenzidine-->C. I. Pigment Red 258-->Pigment Yellow 65-->softener IS-->D-alpha-Tocopheryl acetate-->ACID BLUE 92-->Pigment Yellow 83-->glyceryl ethercarboxylic acid salt-->4-Hydroxy-3-methoxystyrene-->Phenethyl acetate-->7-isopropyl-4-methyloxepan-2-one-->RHODINYL ACETATE

Sodium acetate Ethyl 2-(Chlorosulfonyl)acetate Acetic anhydride SODIUM ACETATE (TRIHYDRATE) FOR HPLC sodium Sodium acetate trihydrate POLY(VINYL ACETATE) Sodium dehydroacetate Cellulose acetate Diclofenac sodium ACETATE Ethyl acetate Glatiramer acetate Sodium bicarbonate Vinyl acetate Ammonium acetate 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Phenylacetic acid

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Sodium acetate trihydrate

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