ChemicalBook Product Catalog Organic Chemistry Nitrile compound 4-Chlorobenzyl cyanide

4-Chlorobenzyl cyanide

4-Chlorobenzyl cyanide Basic information
Product Name:4-Chlorobenzyl cyanide
Synonyms:4-Chlorobenzyl cyanide, 98+% 100GR;4-CHLOROBENZYL CYANIDE FOR SYNTHESIS;The effects of acetonitrile;(4-Chlorophenyl)acetonitrile 96%;4-CHLOROBENZYL CYANIDE;CHLOROBENZYLCYANIDE-4;LABOTEST-BB LT00891700;TIMTEC-BB SBB004060
CAS:140-53-4
MF:C8H6ClN
MW:151.59
EINECS:205-418-9
Product Categories:Aromatic Nitriles
Mol File:140-53-4.mol
4-Chlorobenzyl cyanide Structure
4-Chlorobenzyl cyanide Chemical Properties
Melting point 25-28 °C(lit.)
Boiling point 265-267 °C(lit.)
density 1.19 g/mL at 20 °C(lit.)
refractive index n20/D 1.543
Fp >230 °F
storage temp. Sealed in dry,Room Temperature
solubility 0.3g/l
form Liquid After Melting
color Clear colorless to yellow
BRN 971171
Exposure limitsNIOSH: IDLH 25 mg/m3
InChIKeyIVYMIRMKXZAHRV-UHFFFAOYSA-N
CAS DataBase Reference140-53-4(CAS DataBase Reference)
NIST Chemistry ReferenceBenzeneacetonitrile, 4-chloro-(140-53-4)
EPA Substance Registry SystemBenzeneacetonitrile, 4-chloro- (140-53-4)
Safety Information
Hazard Codes T,Xi
Risk Statements 23/24/25-36/37/38
Safety Statements 26-36/37/39-45-28B
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS AL8250000
Hazard Note Irritant/Toxic
TSCA Yes
HazardClass 6.1
PackingGroup II
HS Code 29269095
MSDS Information
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4-Chlorobenzyl cyanide English
SigmaAldrich English
ACROS English
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4-Chlorobenzyl cyanide Usage And Synthesis
Chemical Propertiesclear colorless to yellowish liquid after melting. Soluble in acetone and ethanol.
Uses4-Chlorobenzyl cyanide is an intermediate for the preparation of 3-methyl-2-(4-chlorophenyl)butyric acid, which can be used to prepare pyrethroid insecticides such as fenvalerate and deltamethrin, and can be used in medicine Industrial preparation of pyrimethamine.
Preparation4-Chlorobenzyl cyanide is obtained by the reaction of 4-Chlorobenzyl chloride with sodium cyanide. Add 4-Chlorobenzyl chloride and Benzyldodecyldimethylammonium bromide into the reaction pot, heat to 100°C, slowly add sodium cyanide aqueous solution, and react at 100-104°C for 5h (add sodium cyanide for 3h, keep warm for 2h). Then add water to dissolve sodium chloride, and separate the water layer to obtain the crude benzyl chloride cyanide, which is distilled under reduced pressure to collect 160 (2.66kPa) fractions to obtain the finished product of 4-Chlorobenzyl cyanide. The yield is above 81%.
DefinitionChEBI: 4-Chlorobenzyl cyanide is a nitrile that is acetonitrile in which one of the hydrogens has been replaced by a p-chlorophenyl group. It is a member of monochlorobenzenes and a nitrile. It derives from an acetonitrile.
1-CYANO-1-(4-CHLOROPHENYL)-2-[(2-METHOXYPHENYL)AMINO]ETHENE 1-CYANO-1-(4-CHLOROPHENYL)-2-[(3-METHOXYPHENYL)AMINO]ETHENE 4-Methoxybenzyl cyanide 4-CHLORO-ALPHA-METHYLPHENYLACETONITRILE 2-(4-CHLOROPHENYL)-3-METHYLBUTYRONITRILE 2-(4-Amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile 3-FLUORO-4-CHLOROBENZYL CYANIDE,3-Fluoro-4-Chloro Phenylacetonitrile 3-Fluoro-4-Chlorobenzyl Cyanide Diphenolic acid 1-(4-Chlorophenyl)-1-cyclopentanecarbonitrile 1-CYANO-1-(4-CHLOROPHENYL)-2-(PHENYLAMINO)ETHENE 3-Chlorobenzyl Cyanide m-Chlorobenzyl Cyanide,M-CHLOROBENZYL CYANIDE,3-CHLOROBENZYL CYANIDE Benzeneacetonitrile 5-Chlorovaleric acid 3-CHLOROBENZYL CYANIDE = 3-CHLOROPHENYLACETONITRILE 1-(4-CHLOROPHENYL)-1-CYCLOPROPANECARBONITRILE HYDROGEN CYANIDE Cyanide 2-(4-Chlorophenyl)-2-cyanoacetaldehyde
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