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| | 5-Bromonicotinic acid Basic information |
| | 5-Bromonicotinic acid Chemical Properties |
| Melting point | 178-180 °C(lit.) | | Boiling point | 259.67°C (rough estimate) | | density | 1.7477 (rough estimate) | | vapor pressure | 0.01Pa at 25℃ | | refractive index | 1.6120 (estimate) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Powder | | pka | 3.08±0.10(Predicted) | | color | White to yellow-gray or light brown | | BRN | 115854 | | InChIKey | FQIUCPGDKPXSLL-UHFFFAOYSA-N | | LogP | 1.17-1.29 at 23.5℃ and pH6.4 | | CAS DataBase Reference | 20826-04-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25 | | WGK Germany | 3 | | RTECS | QT0868000 | | HazardClass | IRRITANT | | HS Code | 29333999 |
| | 5-Bromonicotinic acid Usage And Synthesis |
| Chemical Properties | Light yellow Cryst | | Uses | 5-Bromopyridine-3-carboxylic acid (5-bromonicotinic acid) was used in the synthesis of 3-guanidinomethyl-5-iodopyridine. | | Synthesis Reference(s) | Journal of the American Chemical Society, 70, p. 2381, 1948 DOI: 10.1021/ja01187a020 | | Purification Methods | The acid is recrystallised from H2O and then from EtOH using charcoal. The amide has m 219-219.5o (from aqueous EtOH), and the methyl ester, prepared by addition of ethereal diazomethane, can be purified by sublimation in a vacuum and has m 98-99o. The acid chloride also can be sublimed in vacuo and has m 74-75o and gives the methyl ester in MeOH. [Graf J Prakt Chem 138 244 1933, Bachman & Micucci J Am Chem Soc 70 2381 1948, Garcia et al. J Am Chem Soc 82 4430 1960, Misic-Vokovic et al. J Chem Soc 34 1978, Beilstein 22/2 V 181.] |
| | 5-Bromonicotinic acid Preparation Products And Raw materials |
| Raw materials | 3-Bromo-5-methylpyridine-->Methyl 5-bromonicotinate-->10-methoxy-1,6-dimethylergoline-8beta-methanol-->DIMETHYL 5-BROMOPYRIDINE-2,3-DICARBOXYLATE-->5-Bromonicotinamide-->2,4'-Dibromoacetophenone-->NICOTINYL CHLORIDE HYDROCHLORIDE-->3-Bromoquinoline-->3,5-Dibromopyridine | | Preparation Products | 5-Aminonicotinic acid-->5-Fluoronicotinic acid-->5-AMINO-NICOTINIC ACID METHYL ESTER-->2-(5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)propan-2-ol-->(5-BROMO-PYRIDIN-3-YL)-ACETONITRILE-->3-BroMo-5-(prop-1-en-2-yl)pyridine-->3-Bromo-5-(Chloromethyl)Pyridine Hydrochloride-->3-Bromo-1,5-naphthyridine-->3-Amino-5-bromopyridine |
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