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| | Fmoc-Trp(Boc)-OH Basic information |
| | Fmoc-Trp(Boc)-OH Chemical Properties |
| Melting point | ca 97℃ | | alpha | -21 º (c=1%, DMF) | | density | 1.28±0.1 g/cm3(Predicted) | | refractive index | -20 ° (C=1, DMF) | | storage temp. | 2-8°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Solid | | pka | 3.71±0.10(Predicted) | | color | White to Orange to Green | | optical activity | [α]20/D 21±2°, c = 1% in DMF | | Sensitive | Moisture Sensitive | | BRN | 7698009 | | InChIKey | ADOHASQZJSJZBT-SANMLTNESA-N | | CAS DataBase Reference | 143824-78-6(CAS DataBase Reference) |
| | Fmoc-Trp(Boc)-OH Usage And Synthesis |
| Chemical Properties | White solid | | Uses | Fmoc-Trp(Boc)-OH is a very useful synthetic intermediate. It is used to prepare Trp containing-peptides. | | Uses | Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS). | | General Description | The use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.
The product number for this product was previously 04-12-1103.
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| | Fmoc-Trp(Boc)-OH Preparation Products And Raw materials |
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