ChemicalBook Product Catalog Biochemical Engineering Nucleoside drugs Deoxynucleotides and their analogs 2'-Fluoro-2'-deoxyuridine

2'-Fluoro-2'-deoxyuridine

2'-Fluoro-2'-deoxyuridine Basic information
Product Name:2'-Fluoro-2'-deoxyuridine
Synonyms:1-(2'-FLUORO-2'-DESOXY-BETA-D-RIBOFURANOSYL)URACIL;2,4(1H,3H)-PYRIMIDINEDIONE, 1-(2-DEOXY-2-FLUORO-BETA-D-RIBOFURANOSYL);2'-FLUORO-2'-DEOXYURIDINE;2'-FLUORO-2'-DESOXY-URIDINE;2'-DEOXY-2'-FLUOROURIDINE;2'-FLUORO-D-URIDINE;2'-FUDR;2'-FU
CAS:784-71-4
MF:C9H11FN2O5
MW:246.19
EINECS:1806241-263-5
Product Categories:Bases & Related Reagents;Intermediates & Fine Chemicals;API intermediates;Biochemistry;Nucleotides;Pharmaceuticals;Pyridines, Pyrimidines, Purines and Pteredines;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;784-71-4;Nucleosides
Mol File:784-71-4.mol
2'-Fluoro-2'-deoxyuridine Structure
2'-Fluoro-2'-deoxyuridine Chemical Properties
Melting point 147.0 to 153.0 °C
density 1.63±0.1 g/cm3(Predicted)
refractive index 53 ° (C=0.3, H2O)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble in methanol.
form Powder
pka9.39±0.10(Predicted)
color White to Off-white
InChIInChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
InChIKeyUIYWFOZZIZEEKJ-XVFCMESISA-N
SMILESOC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O
CAS DataBase Reference784-71-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-40
Safety Statements 22-36/37/39
HS Code 29389090
MSDS Information
2'-Fluoro-2'-deoxyuridine Usage And Synthesis
Description2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.
Chemical PropertiesWhite to almost white crystalline powder
Uses2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.
UsesA component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.
2'-Fluoro-2'-deoxyuridine Preparation Products And Raw materials
3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE Fluorine 2'-DEOXY-2'-FLUORO-5-(TRIMETHYLSTANNYL)-URIDINE 2'-FLUORODEOXYURIDINE-5,6-D2 5-Fluoro-2'-deoxyuridine 98%,(+)-5-FLUORO-2'-DEOXYURIDINE,5-FLUORO-2'-DEOXYURIDINE,5-FLUORO-2-DEOXYURIDINE,beta-5-fluoro-2’-deoxyuridin 2'-Fluoro-2'-deoxyuridine 2'-Deoxyuridine Doxifluridine 2',2'-DIFLUORO-2'-DEOXYURIDINE uridine diphosphate glucose {= UDP-glucose} 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE Trifluridine BrdU (Bromodeoxyuridine) 2'-FLUORO-2'DEOXYURIDINE, [5'-3H] 2'-DEOXY-2'-FLUOROTHYMIDINE 2'-DEOXY-2'-FLUOROURIDINE, [3H]- fluoro jade 2'-FLUORO-2'-DEOXYURIDINE-5'-TRIPHOSPHATE LITHIUM SALT
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