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| | Sodium Pyrithione Basic information |
| | Sodium Pyrithione Chemical Properties |
| Melting point | -25 °C | | Boiling point | 109 °C | | density | 1.22 | | vapor pressure | 0-0Pa at 25℃ | | refractive index | 1.4825 | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | H2O: 0.1 M at 20 °C, clear, faintly yellow | | form | Solution | | color | very deep brown | | Water Solubility | 54.7 g/100 mL | | λmax | 334nm(H2O)(lit.) | | Sensitive | Hygroscopic | | Merck | 14,7994 | | BRN | 4026050 | | InChIKey | WNGMMIYXPIAYOB-UHFFFAOYSA-M | | LogP | -2.38 at 20℃ and pH7 | | Surface tension | 65.013-72.6mN/m at 1-1.02g/L and 20-20.1℃ | | CAS DataBase Reference | 3811-73-2(CAS DataBase Reference) | | EPA Substance Registry System | Sodium (2-pyridylthio)-N-oxide (3811-73-2) |
| | Sodium Pyrithione Usage And Synthesis |
| Description | Sodium pyrithione is mainly used for anti-mildew and antibacterial products in the fields of daily chemicals (shampoo and hair care products), architectural coatings, adhesives, sealants, pesticides, textiles, leather products, metal working fluids, etc. It can also be formulated for disinfection agents, detergents and medical broad-spectrum antifungal dermatological products. At the same time, it is also an effective fungicide and an excellent common disinfectant for fruit trees, peanuts, wheat, vegetables and other crops. Its derivative product, zinc pyrithione, is also a commonly used fungicide for daily chemicals.
 | | Chemical Properties | sodium pyrithione belongs to pyridine derivatives fungicide, appearance is yellow full light dumpling transparent liquid, melting point 250 ℃, slightly characteristic odor. Soluble in water and ethanol and other organic solvents, solubility (by mass fraction): water 53%, ethanol 19%, polyethylene glycol (PECG400) 12%. Best use pH range 7 to 10, mass fraction of 2% aqueous solution pH 8.0. Unstable to light, oxidizing agents and strong reducing agents. Non-ionic surfactants will deactivate it somewhat, and it can chelate with heavy metals. | | Uses | sodium pyrithione is a preservative that is not commonly used because of some level of toxicity. It is prohibited in Canada, and it is on the eu Annex II list of substances that must not form part of a cosmetic product composition. | | Uses | Sodium omadine is a bactericide for use in cooling fluids and short-term in-can preservation of vinyl acetate latex, paints, and synthetic-fiber
lubricants; preservative for cosmetic rinse-off products. | | Definition | Apparently exists in equilibrium with the -SH form. Forms chelates with iron, manganese, zinc, etc. | | Application | 2-Mercaptopyridine N-oxide sodium salt is one of the active components in paint, sealants, shampoo, adhesive and aerosol due to its anti-microbial activity. In biochemistry studies, it is utilized to transport zinc into cells. Further, it is used to form bidentate oxothiolane chelates with transition metals. It acts as a stabilizer and viscosity building provider in weak basic or neutral medium. | | Brand name | Sodium Omadine (Olin). | | General Description | 2-Mercaptopyridine N-oxide acts as labelling agent during indium-111 labelling of human platelets. It acts as bioactive ligand and forms palladium and platinum complexes, which were tested as potential antitrypanosomal agents. | | Biochem/physiol Actions | 2-Mercaptopyridine N-oxide is a zinc ionophore that transports zinc into cells. | | Safety Profile | Poison by
intraperitoneal and intravenous routes.
Moderately toxic by ingestion, subcutaneous
and parenteral routes. Used in preservation
of cosmetics. When heated to
decomposition it emits very toxic fumes of
Na2O, NOx, and SOx. See also
MERCAPTANS. | | Purification Methods | When recrystallised from water, it assayed as 98.7% based on AgNO3 titration [Krivis et al. Anal Chem 35 966 1963; see also Krivis et al. Anal Chem 48 1001 1976, and Barton & Crich J Chem Soc, Perkin Trans 1 1603, 1613 1986]. [Beilstein 21/7 V 151.] | | Mode of action | Pyrithione Sodium is the sodium salt form of pyrithione, a fungistatic and antimicrobial derivative of aspergillic acid. Although the exact mechanism of action remains to be fully elucidated, pyrithione sodium appears to interfere with membrane transport ultimately leading to a loss of metabolic control. |
| | Sodium Pyrithione Preparation Products And Raw materials |
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