ChemicalBook Product Catalog Organic Chemistry Amides Acyclic polyamines and their derivatives 2-Chloroethylamine hydrochloride

2-Chloroethylamine hydrochloride

2-Chloroethylamine hydrochloride Basic information
Chemical Properties Application
Product Name:2-Chloroethylamine hydrochloride
Synonyms:2-CHLOROETHYLAMINE MONOHYDROCHLORIDE, 99 %;2-CHLOROPROPYLAMINE·HCL;2-ChloroethylamineHcl99%;2-ChloroethylamineHydrochloride98%;2-CHLOROETHYLAMINE HYDROCHLORIDE (CEA);2-CHLOROETHYLAMINE HYDROCHLORIDE (70% SOLUTION) (CEA LIQ);2-Chloroethylamine hydrochloride, 70 wt.% aqueous solution;2-CHLOROETHYLAMINE MONOHYDROCHLORIDE
CAS:870-24-6
MF:C2H7Cl2N
MW:115.99
EINECS:212-793-2
Product Categories:omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;omega-Haloalkylamines
Mol File:870-24-6.mol
2-Chloroethylamine hydrochloride Structure
2-Chloroethylamine hydrochloride Chemical Properties
Melting point 140-150 °C(lit.)
storage temp. Store below +30°C.
solubility 5666g/l
form Crystalline Powder
color White to light beige
PH2-3 (5666g/l, H2O, 20℃)
Water Solubility SOLUBLE
Sensitive Hygroscopic
BRN 3590304
InChIInChI=1S/C2H6ClN.ClH/c3-1-2-4;/h1-2,4H2;1H
InChIKeyONRREFWJTRBDRA-UHFFFAOYSA-N
SMILESNCCCl.[H]Cl
CAS DataBase Reference870-24-6(CAS DataBase Reference)
EPA Substance Registry System2-Chloroethylamine hydrochloride (870-24-6)
Safety Information
Hazard Codes Xi,C
Risk Statements 36/37/38-68-34
Safety Statements 26-36-37/39-45-36/37/39
RIDADR UN3261
WGK Germany 3
RTECS KR1800000
F 3-10-34
TSCA Yes
HazardClass 8
PackingGroup III
HS Code 29211980
ToxicityLD50 orally in Rabbit: > 2000 mg/kg
MSDS Information
ProviderLanguage
2-Aminoethyl chloride hydrochloride English
ACROS English
SigmaAldrich English
ALFA English
2-Chloroethylamine hydrochloride Usage And Synthesis
Chemical Properties

2-Chloroethylamine hydrochloride (C2H7Cl2N, CAS registry No. 870-24-6) is a white to light beige crystalline powder. It is soluble in water and stable at room temperature in closed containers under normal storage and handling conditions. It should store in a tightly closed container, in a cool, dry, well-ventilated area away from incompatible substances and should be protected from moisture.

Application

2-Chloroethylamine hydrochloride is an important fine chemical intermediate. It can be used for the synthesis of fluvoxamine maleate, which is an important antidepressant drug. 2-Chloroethylamine hydrochloride can also be used as the substrate to synthesize 2-(2'-Aminoaryl)oxazolines and their derivatives, which have been studied as ligands for a variety of metal chelates and are known to possess biological activity in both free ligand and chelated forms. Meanwhile, 2-chloroethylamine hydrochloride can be used for chemical modification of chitosan to improve the biological activity of chitosan.
2-Chloroethylamine hydrochloride can also react with hydroxypropyl starch (HPS) to form aminoethyl hydroxypropyl starch (AEHPS), which can react with collagen peptide (COP) by using microbial transglutaminase (MTGase) as biocatalyst to synthesize aminoethyl hydroxypropyl starch collagen peptide (AEHPS-COP). The AEHPS-COP showed a promising potential application in cosmetic, biomedical and pharmaceutical fields with improved in vitro antioxidant activities.

Chemical PropertiesWHITE TO LIGHT BEIGE CRYSTALLINE POWDER
Uses2-chloroethylamine hydrochloride is used as an intermediate in active pharmaceutical ingredients and dyes. It is also used in organic synthesis. Further, it is employed as a derivatizing reagent for amino acids, dipeptides and nucleotides.
Uses2-Chloroethylamine hydrochloride can be used in the preparation of novel Schiff base ligands. These ligands, when immobilized on silica gels, form inexpensive materials for the removal of metal ions such as Ni2+ and Co2+ ions from contaminated water.
Other applications:
  • Alginate derivatization via aminoethylation to form aminoethyl alginate.
  • Synthesis of N-(2-chloroethyl)-benzaldimine.
  • Derivatization of starch to form aminoethyl (AE-St) starch derivatives.

2-Chloroethylamine hydrochloride Preparation Products And Raw materials
Preparation Products2-Phenoxyethylamine-->Taurine-->N-Aminoethylpiperazine-->2-Imidazol-1-ylethanamine-->2-Chloroethyl isocyanate-->Imidazo[1,2-b]pyridazine-->2-CHLOROETHYL ISOTHIOCYANATE-->selenocystamine-->Pyridine, 2-(4,5-dihydro-2-oxazolyl)- (9CI)-->N-METHYLETHYLENEDIAMINE-->2-(propylthio)ethanamine(SALTDATA: HCl)-->N-(2-Chloroethyl)-3-methoxybenzamide-->(2-Chloroethyl)sulfaMoyl Chloride-->2-(2-methyl-imidazol-1-yl)-ethylamine hydrobromide-->(2-CHLOROETHYL)-4-FLUOROBENZAMIDE
Methylene Chloride Triethylamine hydrochloride 2-Diisopropylaminoethyl chloride hydrochloride N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) LABOTEST-BB LT00441005 2-Chloroethylamine hydrochloride Topotecan hydrochloride Calcium chloride CHLORMEQUAT Diclofenac diethylamine 2-(2-Aminoethylamino)ethanol Ethylamine hydrochloride 2-Dimethylaminoethyl chloride hydrochloride Choline chloride 2,2,2-Trichloroacetamide Diethylamine hydrochloride Cyclophosphamide 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile
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