ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Natural amino acids and derivatives N-EPSILON-ACETYL-L-LYSINE

N-EPSILON-ACETYL-L-LYSINE

N-EPSILON-ACETYL-L-LYSINE Basic information
Product Name:N-EPSILON-ACETYL-L-LYSINE
Synonyms:N-E-ACETYL-L-LYSINE;N-EPSILON-ACETYL-L-LYSINE;H-L-LYS(AC)-OH;(2S)-6-acetamido-2-amino-hexanoic acid;LYSINE(AC)-OH;Nε-Acetyllysine;Nε-Ac-L-Lys-OH;N-epsilon-Acetyl-L-lysine,99%
CAS:692-04-6
MF:C8H16N2O3
MW:188.22
EINECS:211-725-9
Product Categories:A - H;Amino Acids;Modified Amino Acids
Mol File:692-04-6.mol
N-EPSILON-ACETYL-L-LYSINE Structure
N-EPSILON-ACETYL-L-LYSINE Chemical Properties
Melting point 250 °C (dec.)(lit.)
Boiling point 323.23°C (rough estimate)
density 1.1793 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. -20°C
solubility Aqueous Base (Slightly), Water (Slightly)
form Powder
pka2.53±0.24(Predicted)
color White
Water Solubility Soluble in water (miscible), and 80% acetic acid (50 mg/ml).
Sensitive Hygroscopic
InChIKeyDTERQYGMUDWYAZ-ZETCQYMHSA-N
CAS DataBase Reference692-04-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-36-26
WGK Germany 3
HS Code 29241900
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
N-EPSILON-ACETYL-L-LYSINE Usage And Synthesis
DescriptionAcetyllysine (or acetylated lysine) is an acetyl-derivative of the amino acid lysine. There are multiple forms of acetyllysine - this article refers to N-ε-acetyl-L-lysine. The other form is N-α-acetyl-Llysine.
In proteins, the acetylation of lysine residues is an important mechanism of epigenetics. It functions by regulating the binding of histones to DNA in nucleosomes and thereby controlling the expression of genes on that DNA. Non-histone proteins are acetylated as well. Unlike the functionally similar methyllysine, acetyllysine does not carry a positive charge on its side chain.
Histone acetyltransferases (HATs) catalyze the addition of acetyl groups from acetyl-CoA onto certain lysine residues of histones and non-histone proteins. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from acetylated lysines.
Acetyllysine can be synthesized from lysine by the selective acetylation of the terminal amine group.


Chemical Propertieswhite crystalline powder
UsesN-Epsilon-acetyl-l-lysine is used in the metabolomics study on the combined effect of cocaine and ethanol via liquid chromatography-mass spectrometry metabolomics approach.
DefinitionChEBI: An N6-acyl-L-lysine where the N6-acyl group is specified as acetyl.
Biochem/physiol ActionsNε-Acetyl-L-lysine (L-AcK) is an R-chain N-acetylated α amino acid used together with other lysine analogues to differentiate and characterized various aminoacylases and regulator 2 (Sir2) enzymes/sirtuins.
N-EPSILON-ACETYL-L-LYSINE Preparation Products And Raw materials
AC-LYS (AC)-OH Z-LYS(TFA)-OSU BOC-N-EPSILON-ACETYL-L-LYSINE,N-ALPHA-T-BOC-N-EPSILON-ACETYL-L-LYSINE,N-ALPHA-T-BUTOXYCARBONYL-N-EPSILON-ACETYL-L-LYSINE,na-T-boc-N-epsilon-acetyl-L-lysine N-ALPHA-FMOC-N-EPSILON-ACETYL-L-LYSINE,FMOC-N-EPSILON-ACETYL-L-LYSINE,N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-EPSILON-ACETYL-L-LYSINE N-EPSILON-BENZOYL-L-LYSINE N-EPSILON-ACETYL-L-LYSINE 3-(N-MALEIMIDYLPROPIONYL)BIOCYTIN N-6-Trifluoroacetyl-L-lysine DI-N-TFA-L-LYSINE METHYL ESTER BOC-LYS(TFA)-OSU AIAH BIOCYTIN HYDROCHLORIDE FMOC-LYS(PALMITOYL)-OH BOC-BIOCYTIN BOC-LYS(NICOTINOYL)-OH MALEIMIDOBUTYRYLBIOCYTIN L-ASP-L-EPSILON-LYSINE ALPHA-L-GLU-EPSILON-L-LYS
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