|
| | Bis-Propargyl-PEG13 Basic information |
| Product Name: | Bis-Propargyl-PEG13 | | Synonyms: | Bis-Propargyl-PEG13;Bis-propargyl-PEG12;CAS_1351373-50-6;4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne;Bis-propargyl-PEG12/4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne | | CAS: | 1351373-50-6 | | MF: | C30H54O13 | | MW: | 622.74 | | EINECS: | | | Product Categories: | | | Mol File: | 1351373-50-6.mol |  |
| | Bis-Propargyl-PEG13 Chemical Properties |
| solubility | Soluble in Water, DMSO, DMF, DCM |
| | Bis-Propargyl-PEG13 Usage And Synthesis |
| Description | Bis-propargyl-PEG13 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | | in vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | | structure and hydrogen bonding | Bis-propargyl-PEG13 comprises two propargyl groups which can form triazole linkages with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The hydrophilic PEG units help improve the solubility of the molecule in aqueous media. |
| | Bis-Propargyl-PEG13 Preparation Products And Raw materials |
|
