N,N-Diethylacetoacetamide

N,N-Diethylacetoacetamide Basic information

Product Name:	N,N-Diethylacetoacetamide
Synonyms:	N,N-Diethylacetoacetamide Lonza quality, 98.0-100.3% (w/w) (T);N,N-Diethylacetoacetamide;N-ACETOACETYLDIETHYLAMINE;N,N-DIETHYLACETOACETAMIDE;N,N-DIETHYL-3-OXOBUTANAMIDE;DEAA;1-(Diethylcarbamoyl)-2-propanone;Acetoacetamide, N,N-diethyl-
CAS:	2235-46-3
MF:	C8H15NO2
MW:	157.21
EINECS:	218-792-3
Product Categories:	Amides;Carbonyl Compounds;Organic Building Blocks
Mol File:	2235-46-3.mol

N,N-Diethylacetoacetamide Chemical Properties

Melting point	-73 °C
Boiling point	76 °C(lit.)
density	0.994 g/mL at 20 °C (lit.)
vapor pressure	1.387Pa at 25℃
refractive index	n20/D 1.471
Fp	94 °C
storage temp.	Inert atmosphere,Room Temperature
form	clear liquid
pka	12.97±0.46(Predicted)
color	yellow
PH	5-7 (10g/l, H2O, 20℃)
explosive limit	1%(V)
Water Solubility	10g/L at 26℃
BRN	636486
LogP	0.41
CAS DataBase Reference	2235-46-3(CAS DataBase Reference)
NIST Chemistry Reference	Butanamide, N,N-diethyl-3-oxo-(2235-46-3)
EPA Substance Registry System	Butanamide, N,N-diethyl-3-oxo- (2235-46-3)

Safety Information

Safety Statements	24/25
WGK Germany	3
RTECS	AK4025000
TSCA	Yes
HS Code	29241990
Hazardous Substances Data	2235-46-3(Hazardous Substances Data)

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

N,N-Diethylacetoacetamide Usage And Synthesis

Chemical Properties	Clear yellow liquid
Uses	N,N-Diethylacetoacetamide is used as intermediate for the manufacture of insecticides, e.g. phosphamidon Product Data Sheet
Uses	N,N-Diethylacetoacetamide is an intermediate in the synthesis of Phosphamidon (E/Z mixture) (P353730), an organophosphate insecticide that acts as a cholinesterase inhibitor.
Uses	N,N-Diethylacetoacetamide is a β-dicarbonyl compound that ?can be used to synthesize potent calcium channel blockers such as 2,6,6-trimethyl-3-diethylaminocarbonyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives and N,N-diethyl-2,6,6-trimethyl-4-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide. It can also undergo Michael addition in the presence of bis(2,4-pentanedionato)nickel(II) catalyst.
Flammability and Explosibility	Flammable

N,N-Diethylacetoacetamide Preparation Products And Raw materials

Raw materials	Hydrochloric acid-->Dichloromethane-->Thionyl chloride-->Ethyl acetoacetate-->Diethylamine-->tert-Butyl methyl ether-->Acetyl ketene
Preparation Products	a,a-Dichloro-N,N-Diethylacetylacetamide-->2,2-dichloro-N,N-diethyl-3-oxobutyramide

3-[(3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ANILINO)METHYLENE]-1,6,7,11B-TETRAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE-2,4(3H)-DIONE 2,4-DIOXO-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE-3-CARBALDEHYDE O-METHYLOXIME Ethopabate 1-ACETOACETYL-3-METHYLPIPERIDINE 1-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-2-[(DIMETHYLAMINO)METHYLENE]-1,3-BUTANEDIONE Acetoacetamide N,N-Diethylacetoacetamide Diethyl phthalate Acetamide DIACETAMIDE Diethyl ether 3-[(DIMETHYLAMINO)METHYLENE]-1,6,7,11B-TETRAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE-2,4(3H)-DIONE 2,4-DIOXO-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE-3-CARBALDEHYDE O-(2,4-DICHLOROBENZYL)OXIME Thioacetamide Celiprolol Diethyl malonate N,N-Dimethylacetamide 1-ACETOACETYL-4-METHYLPIPERIDINE

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