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| Product Name: | Panthenol | | Synonyms: | 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-,(+-)-Butanamide;4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(+-)-butanamid;4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(+-)-butyramid;4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(+/-)-butanamid;4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-dl-butyramid;DL-2 4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3 3-DIMETHYLBUTYRAMIDE;DL-N-PANTOYL-E-PROPANOLAMINE;DL-PANTOTHENOL | | CAS: | 16485-10-2 | | MF: | C9H19NO4 | | MW: | 205.25 | | EINECS: | 240-540-6 | | Product Categories: | Vitamin Ingredients;Pharmaceutical Intermediates;Inhibitors;ZENTINIC | | Mol File: | 16485-10-2.mol |  |
| | Panthenol Chemical Properties |
| Melting point | 66-69 °C (lit.) | | Boiling point | 118-120 °C(Press: 0.02 Torr) | | alpha | 0°(c=5, H2O) | | density | 1.166±0.06 g/cm3(Predicted) | | vapor pressure | 0.004Pa at 25℃ | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) | | pka | 13.03±0.20(Predicted) | | form | neat | | color | White to Off-White | | Water Solubility | Soluble in water, ethanol, ether, chloroform, and propylene glycol. | | Sensitive | Hygroscopic | | Merck | 14,2947 | | BRN | 1724945 | | InChIKey | SNPLKNRPJHDVJA-UHFFFAOYSA-N | | LogP | -1.02 at 22℃ | | CAS DataBase Reference | 16485-10-2(CAS DataBase Reference) | | EPA Substance Registry System | Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl- (16485-10-2) |
| Hazard Codes | Xn | | Risk Statements | 36/37/38-48-41-37/38-20/21/22 | | Safety Statements | 26-37-45-36/37/39-22 | | WGK Germany | 3 | | RTECS | ES4316500 | | F | 3 | | TSCA | Yes | | HS Code | 29362400 | | Toxicity | mouse,LD50,intraperitoneal,10100mg/kg (10100mg/kg),Farmaco, Edizione Scientifica. Vol. 14, Pg. 43, 1959. |
| | Panthenol Usage And Synthesis |
| General Description | Panthenol (also called pantothenol) is the alcohol analog of pantothenic acid (vitamin B5), and is thus a provitamin of B5. In organisms it is quickly oxidized to pantothenic acid. It is a viscous transparent liquid at room temperature. Panthenol is used as a moisturizer and to improve wound healing in pharmaceutical and cosmetic products.
Panthenol is a multi-functional active ingredient that would be useful in most skin care formulations. Its efficacy has been substantiated in numerous peer-reviewed journals. The biologically active form of Panthenol, D-panthenol (EU), is the stable alcohol analogue of vitamin B5, pantothenic acid (EU), and is quickly converted to vitamin B5 (pantothenate) in the body. Pantothenic acid is present in all living cells and acts as an essential nutritional component due to its role in the formation of acetyl-co-enzyme A in the early stages of metabolism. The main role of acetyl-co-enzyme A is to provide activated acetic acid into the citric acid cycle (Krebs Cycle). This produces carbon dioxide, water, and energy. Co-enzyme A also transfers to other molecules such as Nacetyl-glucosamine (EU) and acetylcholine (EU) to help in the production of steroids and the synthesis of fatty acids. Coenzyme A also helps the body detoxify foreign substances.
| | Uses | Panthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium.
Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties. The vitamin ingredient Panthenol is valued in skin and hair care applications for its moisturizing properties. It has anti-inflammatory effects and soothes irritated and sensitive skin. For hair care application it is known for its humectant properties and its ability to improve the resistance of hair to mechanical stress. | | Mechanism of action | Pantothenic acid is a precursor of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups. The final step in the synthesis of
acetylcholine consists of the choline acetylase transfer of acetyl group from acetylcoenzyme A to choline. Acetylcholine is the neurohumoral transmitter in the parasympathetic system and as such
maintains the normal functions of the intestine. Decrease in acetylcholine content would result in decreased peristalsis and in extreme cases adynamic ileus.
Panthenol is well absorbed into the skin and quickly converted into Pantothenic acid by oxidation. Pantothenic acid is distributed into the cells and is converted to Acetyl Coenzyme-A (Acetyl CoA)
in the cells of the epidermis. Human being require Vitamin B5 to synthesize Acetyl CoA which is an essential mediator to many biochemical reactions that sustain life (maintenance and repair of all
cells) and which breaks down fats, carbohydrates and proteins for carbon dioxide, water, and energy generation. Furthermore, it synthesis fatty acids and sphingolipids, for stratum corneum lipid
layers and cell membrane integrity & fluidity. | | Side effects | Panthenol is generally well tolerated. In rare cases, skin irritation and contact allergies have been reported. Generally, topical panthenol formulations were well tolerated with minimal risk of skin irritation or sensitization. | | Uses | vitamin B5 precursor, radioprotectant, antimalarial | | Uses | DL-Panthenol is used in the topical treatment of skin disorders, such as minor irritations and skin burns. Also used in the strengthening and treatment of hair. | | Uses | panthenol (pro-vitamin B5) acts as a penetrating moisturizer. Panthenol appears to stimulate cellular proliferation and aid in tissue repair. Studies indicate that when topically applied, panthenol penetrates the skin and gets converted into pantothenic acid, a B complex vitamin. Such action could possibly influence the skin’s natural resources of pantothenic acid. It imparts a nonirritant, non-sensitizing, moisturizing, and conditioning feel and promotes normal keratinization and wound-healing. Panthenol protects the skin against sunburn, provides relief for existing sunburn, and enhances the natural tanning process. Panthenol’s humectant character enables it to hold water in the product or attract water from the environment, resulting in a moisturizing effect. It enhances skin suppleness, and claims are that it also acts as an anti-inflammatory agent. It is considered a non-comedogenic raw material. | | General Description | Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Panthenol exists in two optically active forms, both of which are used in pharmaceutical preparations. While pantothenic acid is optically active, only the dextrorotatory form is biologically active. Dexpanthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium. | | Flammability and Explosibility | Nonflammable |
| | Panthenol Preparation Products And Raw materials |
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