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APST-ZA

APST-ZA Basic information
Product Name:APST-ZA
Synonyms:APST-ZA;4-Amino-2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1H-isoindole-1,3(2H)-dione;Apremilast N-desacetyl impurity;Apremilast Impurity P;Apremilast Impurity AND;Des-acetyl Apremilast;Apremilast N-Desacetyl Imurity;1H-Isoindole-1,3(2H)-dione, 4-amino-2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-
CAS:635705-72-5
MF:C20H22N2O6S
MW:418.46
EINECS:
Product Categories:
Mol File:635705-72-5.mol
APST-ZA Structure
APST-ZA Chemical Properties
Melting point >95°C (dec.)
Boiling point 673.6±55.0 °C(Predicted)
density 1.383±0.06 g/cm3(Predicted)
storage temp. Refrigerator, under inert atmosphere
solubility Chloroform (Slightly), DMSO (Slightly)
pka-0.76±0.20(Predicted)
form Solid
color Off-White to Yellow
Safety Information
MSDS Information
APST-ZA Usage And Synthesis
UsesDes-acetyl Apremilast is the metabolite of Apremilast (A729700), which is an oral phosphodiesterase 4 inhibitor used in the treatment of psoriatic arthritis.
APST-ZA Preparation Products And Raw materials
(S)-N-(2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide (R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide Apremilast Impurity 1 Apremilast Impurity E Apremilast Impurity 21 Apremilast (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Apremilast Impurity 1/2 Apremilast Impurity 8 Apremilast Impurity 13 Apremilast Impurity 28 Apremilast Impurity 25 Apremilast-d8 3-acetamidophthalic acid Apremilast Impurity 2 Apremilast Impurity 9 Apremilast impurity 18 Apremilast Impurity 15
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