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| | RG-7388 Basic information |
| Product Name: | RG-7388 | | Synonyms: | 4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid;RG 7388;RG-7388;RG-7388, Idasanutlin;Idasanutlin (RG-7388);4-[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimet;RG 7388; RG-7388; RG7388;4-{[(2R,3S,4R,5S)-4-(4-Chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid | | CAS: | 1229705-06-9 | | MF: | C31H29Cl2F2N3O4 | | MW: | 616.48 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1229705-06-9.mol |  |
| | RG-7388 Chemical Properties |
| Melting point | >261° (dec.) | | Boiling point | 737.3±60.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 4.11±0.10(Predicted) | | form | Solid | | color | White to Off-White |
| | RG-7388 Usage And Synthesis |
| Description | Potent MDM2 inhibitor with an IC50 = 6 nM in binding assay and 30 nM in cancer cell proliferation assay. Induces p53 stabilisation, cell cycle arrest and apoptosis in cancer cells expression wildtype p53. Displays inhibition of tumor growth in the SJSA1 tumor xenograft model. Also inhibits MDR-1 at high concentrations. | | Uses | Idasanutlin is an MDM2 inihibtor, blocking the p53 protein-protein interaction and may be used in anti-cancer treatments. | | storage | Store at -20°C |
| | RG-7388 Preparation Products And Raw materials |
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