1-Chloro-4-iodobenzene

1-Chloro-4-iodobenzene Basic information

Product Name:	1-Chloro-4-iodobenzene
Synonyms:	1-Chloro-4-iodobenzene, 97+%;Chloro-4-iodobenz;P-IODOCHLOROBENZENE;P-CHLOROIODOBENZENE;1-chloro-4-iodo-benzen;4-Chlorophenyl iodide;1-Chloro-4-iodobenze;1-Chloro-4-iodobenzene, 99% 25GR
CAS:	637-87-6
MF:	C6H4ClI
MW:	238.45
EINECS:	211-305-5
Product Categories:	Chlorine Compounds;Iodine Compounds;White to light yellowcrystalline powder;Aryl;C6;Halogenated Hydrocarbons
Mol File:	637-87-6.mol

1-Chloro-4-iodobenzene Chemical Properties

Melting point	53-54 °C(lit.)
Boiling point	226-227 °C(lit.)
density	1.8860
Fp	227 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form	Crystalline Powder or Crystals
color	Off-white to light beige
Sensitive	Light Sensitive
BRN	1634414
InChIKey	GWQSENYKCGJTRI-UHFFFAOYSA-N
CAS DataBase Reference	637-87-6(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-chloro-4-iodo-(637-87-6)
EPA Substance Registry System	Benzene, 1-chloro-4-iodo- (637-87-6)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	20/21/22-36/37/38
Safety Statements	36/37-24/25
WGK Germany	3
TSCA	T
HazardClass	IRRITANT
HS Code	29039990

MSDS Information

Provider	Language
1-Chloro-4-iodobenzene	English
ACROS	English
SigmaAldrich	English
ALFA	English

1-Chloro-4-iodobenzene Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	suzuki reaction
Uses	4-Chloroiodobenzene is used as a reagent in the synthesis of Clothiapine (C588550); an atypical antipsychotic of the dibenzothiazepine chemical class that has shown efficacy in treatment-resistant schizophrenic patients.
Purification Methods	Distil it in a vacuum then recrystallise it from EtOH. [Sugden J Chem Soc 1173 1924, Beilstein 5 H 221, 5 III 579, 5 IV 695.]

1-Chloro-4-iodobenzene Preparation Products And Raw materials

Raw materials

Benzene, 1-iodo-4-(trimethylsilyl)-

Preparation Products

4-Chloro-alpha-methylstyrene-->4-Chlorophenylacetylene-->4-Chlorobenzaldehyde-->4-Chlorophenylboronic acid-->4-Chlorobenzotrifluoride-->1,4-Bis(trifluoromethyl)-benzene-->4-CHLOROBENZOYLACETONITRILE-->Propiolic acid, (p-chlorophenyl)- (8CI)-->4,4'-DICHLOROBUTYROPHENONE-->4'-CHLORO-BIPHENYL-4-YLAMINE-->4-CHLOROPHENYLSULFONYLACETONITRILE-->5-(4-CHLOROPHENYL)-2-FURALDEHYDE-->4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)CHLOROBENZENE-->(4-BROMOBENZYL)(4-CHLOROPHENYL)SULFANE

Chlorantraniliprole 1,3-DICHLORO-4-IODOBENZENE Phenoxyacetyl chloride 1,4-Diiodobenzene Iodobenzene 3,4-Dichloroiodobenzene 2,4,6-Trichloroiodobenzene 2-Iodobenzoic acid (S)-Amlodipine 1-IODO-2,4,5-TRICHLOROBENZENE 5-CHLORO-2-IODOBENZOTRIFLUORIDE 1-Chloro-4-iodobenzene 3,5-DICHLORO-2-IODOTOLUENE 1-Bromo-4-iodobenzene 1-CHLORO-4-IODO-2,5-DIMETHOXYBENZENE 2-Chloro-5-iodobenzene 5-CHLORO-2-IODOTOLUENE 4-Chlorotoluene

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