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| | TAE226 (NVP-TAE226) Basic information |
| Product Name: | TAE226 (NVP-TAE226) | | Synonyms: | NVP-TAE 226;TAE226;TAE226 (NVP-TAE226);2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide;Benzamide, 2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-;NVP-TAE 226 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide;2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide;TAE226 (NVP-TAE226), >98% | | CAS: | 761437-28-9 | | MF: | C23H25ClN6O3 | | MW: | 468.94 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 761437-28-9.mol |  |
| | TAE226 (NVP-TAE226) Chemical Properties |
| density | 1.349 | | storage temp. | Store at -20°C | | solubility | ≥23.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH | | form | solid | | pka | 14.57±0.46(Predicted) |
| | TAE226 (NVP-TAE226) Usage And Synthesis |
| Description | NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC50 = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC50 = 5 nM). It can also inhibit the insulin-like growth factor 1 receptor (IC50 = 0.16 μM) as well as the activity of its downstream target genes such as MAPK and Akt. NVP-TAE226 has been shown to inhibit glioma and ovarian tumor growth in in vivo tumor models. | | Uses | NVP-TAE 226 is FAK and IGF-IR inhibitor. It can be used in biological study and therapeutic use of TAE226, a bis-?anilino pyrimidine compound, inhibits the egfr-?mutant kinase including T790M mutant to show anti-?tumor effect on EGFR-?mutant non-?small cell lung cancer cells. | | Definition | ChEBI: 2-[[5-chloro-2-[2-methoxy-4-(4-morpholinyl)anilino]-4-pyrimidinyl]amino]-N-methylbenzamide is a member of morpholines. | | target | PYK2 | | references | [1]. liu, t.j., et al., inhibition of both focal adhesion kinase and insulin-like growth factor-i receptor kinase suppresses glioma proliferation in vitro and in vivo. mol cancer ther, 2007. 6(4): p. 1357-67.
[2]. plaza-menacho, i., et al., focal adhesion kinase (fak) binds ret kinase via its ferm domain, priming a direct and reciprocal ret-fak transactivation mechanism. j biol chem, 2011. 286(19): p. 17292-302. |
| | TAE226 (NVP-TAE226) Preparation Products And Raw materials |
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