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| | Isosorbide 5-mononitrate Basic information |
| | Isosorbide 5-mononitrate Chemical Properties |
| Melting point | 88-93 °C | | alpha | 170 º (c=1, EtOH) | | Boiling point | 326.86°C (rough estimate) | | density | 1.5784 (rough estimate) | | refractive index | 145 ° (C=5, H2O) | | storage temp. | -20°C Freezer | | solubility | Undiluted isosorbide mononitrate is freely soluble in water, in acetone, in ethanol (96 per cent) and in methylene chloride. The solubility of the diluted product depends on the diluent and its concentration. | | pka | 13.09±0.40(Predicted) | | form | Solid | | color | White to Off-White | | Water Solubility | soluble | | Merck | 5225 | | InChIKey | YWXYYJSYQOXTPL-SLPGGIOYSA-N | | CAS DataBase Reference | 16051-77-7(CAS DataBase Reference) | | EPA Substance Registry System | D-Glucitol, 1,4:3,6-dianhydro-, 5-nitrate (16051-77-7) |
| Hazard Codes | Xi-F,Xi,F | | Risk Statements | 36/37/38-11 | | Safety Statements | 37/39-16-15 | | RIDADR | 3251 | | RTECS | LZ4386500 | | HazardClass | 4.1 | | HS Code | 2932999000 | | Toxicity | LD50 oral in rat: 2010mg/kg |
| | Isosorbide 5-mononitrate Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde | | Uses | antidepressant, 5HT reuptake inhibitor | | Uses | Isosorbide 5-Mononitrate is a metabolite of Isosorbide Dinitrate; used as an antianginal. | | Uses | A metabolite of Isosorbide Dinitrate. Used as an antianginal | | Definition | ChEBI: Isosorbide mononitrate is a nitrate ester and a glucitol derivative. It has a role as a nitric oxide donor and a vasodilator agent. | | Brand name | Imdur (Schering-Plough); Ismo (Dr. Reddy’s);
Monoket (Schwarz Pharma)
. | | General Description | Isosorbide 5-mononitrate is a crystalline solid. Isosorbide 5-mononitrate is very flammable and may be toxic by ingestion. | | Air & Water Reactions | Highly flammable. | | Reactivity Profile | The dinitrate, a heart drug, can detonate when dry, but is non explosive with 30% of water [J. Haz.. Mater., 1992, 32(1), 87]. The mononitrate would be expected to be less reactive. | | Health Hazard | Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution. | | Fire Hazard | Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished. | | Clinical Use | Vasodilator:
Treatment and prophylaxis of angina
Adjunct in congestive heart failure |
| | Isosorbide 5-mononitrate Preparation Products And Raw materials |
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