Tubacin

Tubacin Basic information
Product Name:Tubacin
Synonyms:Tubacin;N1-(4-((2R,4R,6S)-4-((4,5-diphenyloxazol-2-ylthio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide;N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide Tubacin;N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide;Tubacin, >=98%;BML-GR362;N1-(4-((2R,4R,6S)-4-(((4,5-Diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-di;Tubacin (BML-GR362)
CAS:537049-40-4
MF:C41H43N3O7S
MW:721.86
EINECS:
Product Categories:Inhibitors
Mol File:537049-40-4.mol
Tubacin Structure
Tubacin Chemical Properties
Melting point 155 - 157°C
storage temp. -20°C
solubility DMSO: ≥10mg/mL
form powder
color white to tan
Safety Information
WGK Germany 3
MSDS Information
Tubacin Usage And Synthesis
UsesTubacin is tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC6).
DefinitionChEBI: N-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide is a member of 1,3-oxazoles.
Biochem/physiol ActionsTubacin triggers the release of reactive oxygen species and mediates caspase-3-independent apoptosis of Epstein-Barr virus (EBV)-positive Burkitt lymphoma cells. It suppresses the proliferation of acute lymphoblastic leukemia (ALL) cells and enhances the effect of chemotherapy to treat ALL cells. Tubacin prevents the epileptic activity and neuronal migration defects caused due to lowered expression of Srpx2 in rats.
targetHDAC6
Tubacin Preparation Products And Raw materials
Parthenolide M344 HC TOXIN Entinostat Tubastatin-A OXAMFLATIN Mocetinostat (MGCD0103) CAY10603 APICIDIN BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE Sodium 4-phenylbutyrate SPLITOMICIN Nexturastat A SCRIPTAID Tacedinaline 1H-Benz[de]isoquinoline-2(3H)-butanamide TRICHOSTATIN A ACY-1215

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