ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Glycine derivative DL-Propargylglycine

DL-Propargylglycine

DL-Propargylglycine Basic information
Product Name:DL-Propargylglycine
Synonyms:2-Aminopent-4-ynoic acid hydrochloride;2-Amino-4-pentynoic acid hydrochloride;DL-Propargylglycine HCl;2-amino-4-pentynoic Acid Hydrochloride (1:1);DL-2-Propynylglycine hydrochloride
CAS:16900-57-5
MF:C5H8ClNO2
MW:149.57
EINECS:
Product Categories:
Mol File:16900-57-5.mol
DL-Propargylglycine Structure
DL-Propargylglycine Chemical Properties
storage temp. Inert atmosphere,Room Temperature
solubility DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
form A crystalline solid
Safety Information
MSDS Information
DL-Propargylglycine Usage And Synthesis
DescriptionHydrogen sulphide (H2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator. DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H2S synthesis activity in rat liver preparations with an IC50 value of 55 μM and abolishes the rise in plasma H2S in anaesthetized rats induced with hemorrhagic shock. At concentrations ranging from 25-100 mg/kg, PAG can reduce H2S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.
UsesDL-Propargylglycine Hydrochloride is used in preparation of tert-Butoxycarbonyl Azide.
DL-Propargylglycine Preparation Products And Raw materials
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