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| | Phthalide Basic information |
| | Phthalide Chemical Properties |
| Melting point | 71-74 °C (lit.) | | Boiling point | 290 °C (lit.) | | density | 1.1 | | refractive index | 1.5360 (estimate) | | FEMA | 4195 | PHTHALIDE | | Fp | 152 °C | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Crystalline Powder | | color | White to light beige | | Odor | at 100.00 %. sweet tonka coumarin powdery coconut phenolic lactonic | | Odor Type | coumarinic | | Water Solubility | sparingly soluble | | BRN | 114632 | | InChIKey | WNZQDUSMALZDQF-UHFFFAOYSA-N | | LogP | 0.99 | | CAS DataBase Reference | 87-41-2(CAS DataBase Reference) | | NIST Chemistry Reference | 1(3H)-Isobenzofuranone(87-41-2) | | EPA Substance Registry System | Phthalide (87-41-2) |
| | Phthalide Usage And Synthesis |
| Description |
White powder; sweet tonka, coumarin, powdery, coconut, phenolic, lactonic aroma.
| | Uses | Phthalide may be used in scaffolds for the design of high potency monoamine oxidase (MAO) inhibitors. | | Definition | ChEBI: A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group. | | Aroma threshold values | Low strength odor, Tonka type. | | Taste threshold values | Sweet coumarin, coconut, creamy, anisic, green vegetable, floral taste at 100 ppm in water. | | Synthesis Reference(s) | Chemistry Letters, 23, p. 1149, 1994
The Journal of Organic Chemistry, 68, p. 9423, 2003 DOI: 10.1021/jo0350763
Tetrahedron Letters, 7, p. 6097, 1966 | | Flammability and Explosibility | Notclassified | | Pharmacology | Systemic fungicide giving effective preventive
control of the rice blast fungus in rice as foliar spray. | | Purification Methods | Crystallise phthalide from water (75mL/g) and dry it in air on filter paper. [Beilstein 17/10 V 7.] | | Toxicity evaluation | Mammalian toxicology. Oral: Acute oral
LD50 for rats and mice >10000 mg/kg. Skin and eye: Acute
percutaneous LD50 for rats and mice >10000 mg/kg. Not
a shaved skin irritant, eye irritant (rabbits). Inhalation
LC50 (4 h) for rats >4.1 mg/L air. NOEL: (2 yr) for rats
2000, mice 100 mg/kg diet. |
| | Phthalide Preparation Products And Raw materials |
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