|
| | GW 842166X Basic information |
| Product Name: | GW 842166X | | Synonyms: | GW 842166X;GW 842166;GW842166X/GW-842166X;2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid [(tetrahydropyran-4-yl)methyl]amide;2-(2,4-dichlorophenylamino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide;2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide;GW842166X;GW 842166;CS-631 | | CAS: | 666260-75-9 | | MF: | C18H17Cl2F3N4O2 | | MW: | 449.25 | | EINECS: | 200-258-5 | | Product Categories: | Inhibitors | | Mol File: | 666260-75-9.mol |  |
| | GW 842166X Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF:20.0(Max Conc. mg/mL);44.52(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.56(Max Conc. mM)
DMSO:37.77(Max Conc. mg/mL);84.07(Max Conc. mM)
Ethanol:0.3(Max Conc. mg/mL);0.67(Max Conc. mM) | | form | Powder |
| | GW 842166X Usage And Synthesis |
| Description | The peripheral cannabinoid (CB2) receptor is a G protein-coupled receptor (GPCR) that is localized predominantly in immune cells, monocytes, macrophages, and in several peripheral organs and binds the active component of cannabis, Δ9-tetrahydrocannabinol, as well as anandamide, an endogenous CB receptor ligand. GW 842166X is a peripheral cannabinoid (CB2) receptor agonist with ED50 values of 91 and 63 nM in rat and human, respectively. When administered orally to rats in the Freund’s complete adjuvant (FCA) model of inflammatory pain, GW 842166X is highly potent with an ED50 value of 0.1 mg/kg and full reversal of hyperalgesia at 0.3 mg/kg. | | Uses | GW-842166X is pyrimidine ester based compound that is known as a highly selective CB2 receptor agonist for the treatment of inflammatory and neuropathic pain. | | Definition | ChEBI: 5-pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-n-[(tetrahydro-2h-pyran-4-yl)methyl]-4-(trifluoromethyl)- is a dichlorobenzene. |
| | GW 842166X Preparation Products And Raw materials |
|
