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| | 7-ISOPROPYLISATIN Basic information |
| Product Name: | 7-ISOPROPYLISATIN | | Synonyms: | 7-ISOPROPYLISATIN;UKRORGSYN-BB BBV-030970;1H-Indole-2,3-dione, 7-(1-methylethyl)-;7-Isopropylindoline-2,3-dione | | CAS: | 57816-97-4 | | MF: | C11H11NO2 | | MW: | 189.21 | | EINECS: | | | Product Categories: | | | Mol File: | 57816-97-4.mol |  |
| | 7-ISOPROPYLISATIN Chemical Properties |
| Melting point | 196-198 °C(Solv: dichloromethane (75-09-2)) | | density | 1.200±0.06 g/cm3(Predicted) | | pka | 9.81±0.20(Predicted) | | InChI | InChI=1S/C11H11NO2/c1-6(2)7-4-3-5-8-9(7)12-11(14)10(8)13/h3-6H,1-2H3,(H,12,13,14) | | InChIKey | XWJSENVAAAAHBN-UHFFFAOYSA-N | | SMILES | N1C2=C(C=CC=C2C(C)C)C(=O)C1=O |
| | 7-ISOPROPYLISATIN Usage And Synthesis |
| Uses | 7-Isopropyl-1H-indole-2,3-dione is used in the synthetic preparation of 2-aminoquinazoline derivatives as PLK1 inhibitor useful in treatment of various diseases. | | Synthesis | To concentrated sulfuric acid at 80° C. was added 2-hydroxyimino-N-(2-isopropyl-phenyl)-acetamide in several small portions over 10 minutes. After addition it was heated at 80° C. for 30 minutes., then poured into ice. Filtration, washing with water, and drying under vacuum over P2O5 provided 2.974 g (84%) of 7-Isopropyl-1H-indole-2,3-dione as a solid.
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| | 7-ISOPROPYLISATIN Preparation Products And Raw materials |
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