BENDROFLUMETHIAZIDE

BENDROFLUMETHIAZIDE Basic information
Product Name:BENDROFLUMETHIAZIDE
Synonyms:BENDROFLUMETHIAZIDE;BENDROFLUMETHIAZIDE-D5;1,1-dioxo-3-(phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;3-(benzyl)-1,1-diketo-6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;rac Bendroflumethiazide;Bendroflumethiazide (200 mg);Bendroflumethiazide (200 mg)H0C4020.994mg/mg(ai);6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine,1,1
CAS:73-48-3
MF:C15H14F3N3O4S2
MW:421.41
EINECS:200-800-1
Product Categories:Isotope;BISOLVON;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:73-48-3.mol
BENDROFLUMETHIAZIDE Structure
BENDROFLUMETHIAZIDE Chemical Properties
Melting point 205-207°C
Boiling point 602.1±65.0 °C(Predicted)
density 1.4711 (estimate)
storage temp. Refrigerator
solubility Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent).
pkapKa 8.53±0.05(H2O t=25 I=0.2) (Uncertain)
form neat
color Crystals from MeOH/CHCl3
Water Solubility 40mg/L(room temperature)
EPA Substance Registry System2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide (73-48-3)
Safety Information
WGK Germany 2
RTECS DK8225000
HS Code 2935904000
Hazardous Substances Data73-48-3(Hazardous Substances Data)
ToxicityLD50 oral in mouse: > 10gm/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
BENDROFLUMETHIAZIDE Usage And Synthesis
DescriptionBendroflumethiazide (Item No. 21311) is an analytical reference standard categorized as a diuretic. Diuretics, including bendroflumethiazide, have been abused as performance-enhancing drugs and masking agents in sports doping. This product is intended for research and forensic applications.
Chemical PropertiesWhite Solid
OriginatorNaturetin,Squibb,US,1959
Usesexpectorant
UsesDiuretic; antihypertensive.
UsesBendroflumethiazide may be used for the same indications as the aforementioned drugs; however, it is primarily used as an adjuvant agent for relieving edema associated with cardiac insufficiency, liver cirrhosis, and edema caused by taking corticosteroids.
DefinitionChEBI: A sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group.
Manufacturing ProcessThe process is described in US Patent 3,392,168 as follows:
(A) Preparation of 5-Trifluoromethylaniline-2,4-Disulfonylchloride - 113 ml of chlorosulfonic acid is cooled in an ice bath, and to the acid is added dropwise while stirring 26.6 grams of α,α,α-trifluoro-m-toluidine. 105 grams of sodium chloride is added during 1-2 hours, where after the temperature of the reaction mixture is raised slowly to 150° - 160°C which temperature is maintained for three hours. After cooling the mixture, ice-cooled water is added, whereby 5-trifluoromethylaniline-2,4-disulfonyl chloride separates out from the mixture.
(B) Preparation of 5-Trifluoromethyl-2,4-Disulfamylaniline - The 5- trifluoromethylaniline-2,4-disulfonyl chloride obtained in step (A) is taken up in ether and the ether solution dried with magnesium sulfate. The ether is removed from the solution by distillation, the residue is cooled to 0°, and 60 ml of ice-cooled, concentrated ammonia water is added while stirring. The solution is then heated for one hour on a steam bath and evaporated in vacuo to crystallization. The crystallized product is 5-trifluoromethyl-2,4- disulfamylaniline, which is filtered off, washed with water and dried in a vacuum-desiccator over phosphorus pentoxide. After recrystallization from a mixture of 30% ethanol and 70% water, the compound has a MP of 247°- 248°C.
(C) Preparation of 3-Benzyl-6-Trifluoromethyl-7-Sulfarnyl-3,4-Dihydro-1,2,4- Benzothiadiazine-1,1-Dioxide - 6.4 grams of 5-trifluoromethyl-2,4- disulfamylaniline is dissolved in 12 ml of dioxane, 2.7 ml of phenylacetaldehyde and a catalytic amount of p-toluenesulfonic acid are added. After boiling for a short time under reflux, the reaction mixture crystallizes, and, after filtration and recrystallization from dioxane, the desired product is obtained with a MP of 224.5°-225.5°C.
(D) Alternative to (C) - 9.6 grams of 5-trifluoromethyl-2,4-disulfarnylaniline and 4.9 grams of ω-ethoxystyrene are dissolved in 35 ml of n-butanol. 0.5 grams of p-toluenesulfonic acid is added, and the mixture is heated on a steam bath while stirring. When the solution is clear, 55 ml of hexane is added, whereafter the mixture is heated further for one and a half hours. After cooling, the substance identical to that of Example (C) is filtered off and has a MP of 222°-223°C.
Sterile compositions containing Bendroflumethiazide for parenteral administration may be prepared as described in US Patent 3,265,573.




Brand nameNaturetin (Apothecon).
Therapeutic FunctionDiuretic, Antihypertensive
Clinical UseThiazide diuretic:

Hypertension

Oedema



Safety ProfilePoison by intravenous route.Human systemic effects by ingestion: convulsions andsomnolence. Mutation data reported. When heated todecomposition it emits toxic fumes of F-, SOx, and NOx.
SynthesisBendroflumethiazide, 1,1-dioxide 3-benzyl-6-(trifluoromethyl)- 3,4-dihydro-2H-1,2,4-benzothiadiazin-7-sulfonamide (21.3.6), is synthesized by the same scheme of making the aforementioned drugs using phenylacetaldehyde or its acetale as a carbonyl component, and using 2,4-disulfonamido-5-trifluoromethylaniline (21.3.5) as an o-aminosulfonamide component.

Synthesis_73-48-3

Drug interactionsPotentially hazardous interactions with other drugs
Analgesics: increased risk of nephrotoxicity with NSAIDs; antagonism of diuretic effect.
Anti-arrhythmics: hypokalaemia leads to increased cardiac toxicity; effects of lidocaine and mexiletine antagonised.
Antibacterials: avoid administration with lymecycline.
Antidepressants: increased risk of hypokalaemia with reboxetine; enhanced hypotensive effect with MAOIs; increased risk of postural hypotension with tricyclics.
Antiepileptics: increased risk of hyponatraemia with carbamazepine.
Antifungals: increased risk of hypokalaemia with amphotericin.
Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotension with postsynaptic alpha-blockers like prazosin; hypokalaemia increases risk of ventricular arrhythmias with sotalol.
Antipsychotics: hypokalaemia increases risk of ventricular arrhythmias with amisulpride; enhanced hypotensive effect with phenothiazines; hypokalaemia increases risk of ventricular arrhythmias with pimozide - avoid.
Atomoxetine: hypokalaemia increases risk of ventricular arrhythmias.
Cardiac glycosides: increased toxicity if hypokalaemia occurs.
Ciclosporin: increased risk of nephrotoxicity and hypomagnesaemia. Cytotoxics: increased risk of ventricular arrhythmias due to hypokalaemia with arsenic trioxide; increased risk of nephrotoxicity and ototoxicity with platinum compounds. Lithium excretion reduced, increased toxicity.
MetabolismThere are indications that bendroflumethiazide is fairly extensively metabolised. About 30% is excreted unchanged in the urine with the remainder excreted as uncharacterised metabolites.
BENDROFLUMETHIAZIDE Preparation Products And Raw materials
Raw materialsIron-->Benzotrifluoride-->3-Aminobenzotrifluoride-->Benzotrichloride-->Phenylacetaldehyde-->3-Nitrobenzotrifluoride-->Ammonia-->Chlorosulfonic acid
Bisacodyl Bumetanide BENDROFLUMETHIAZIDE EPB(CRM STANDARD) 2-(Trifluoromethyl)benzenesulfonamide Benzenesulfonamide, 2-(methylamino)- (9CI) 2-AMINO-N-METHYLBENZENESULFONAMIDE BENDROFLUMETHIAZIDE BENDROFLUMETHIAZIDE USP(CRM STANDARD) N-phenethylmethanesulphonamide HYDROFLUMETHIAZIDE BENDROFLUMETHIAZIDE IMP. A (EP): 4-AMINO-6-(TRIFLUOROMETHYL)BENZENE-1,3-DISULPHONAMIDE 4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide 2-(TRIFLUOROMETHYL)THIOPHENOL BENDROFLUMETHIAZIDE IMPURITY A 4-(Trifluoromethyl)benzenesulfonamide 2-amino-N-propylbenzenesulfonamide 2-AMINO-4-(TRIFLUOROMETHYL)THIOPHENOL3-AMINO-4-MERCAPTOBENZOTRIFLUORIDE 2-Aminobenzenesulfonamide

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.