2-(Hydroxymethyl)pyridine

2-(Hydroxymethyl)pyridine Basic information
Product Name:2-(Hydroxymethyl)pyridine
Synonyms:2-Pyridine methanol(2-hydromethyl pyridine);2-HYDROXYMETHYLPYRIDINE(PYRIDINE-2-CARBINOL);2-Pyridinemethanol,ω-Hydroxy-2-picoline, 2-(Hydroxymethyl)pyridine, 2-Pyridyl carbinol;2-(Hydroxymethyl)pyr;2-HYDROXYMETHYL PYRIDINE PYRIDIN-2-YL-METHANOL;PYRIDINE-2-METHANOL (2-PYRIDYLCARBINOL);2-Pyridine Methanol 99%;ω-Hydroxy-2-picoline, 2-(Hydroxymethyl)pyridine, 2-Pyridyl carbinol
CAS:586-98-1
MF:C6H7NO
MW:109.13
EINECS:209-592-7
Product Categories:Building Blocks;C6;Pyridine;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines;bc0001
Mol File:586-98-1.mol
2-(Hydroxymethyl)pyridine Structure
2-(Hydroxymethyl)pyridine Chemical Properties
Melting point 5 °C
Boiling point 112-113 °C/16 mmHg (lit.)
density 1.131 g/mL at 25 °C (lit.)
vapor pressure 3.47Pa at 25℃
refractive index n20/D 1.543(lit.)
Fp >230 °F
storage temp. 2-8°C
solubility miscible
form Liquid
pka13.48±0.10(Predicted)
color Clear colorless to yellow or brown
Specific Gravity1.131
PH6-8 (100g/l, H2O, 20℃)
Odorpyridine odor
Water Solubility miscible
Sensitive Hygroscopic
BRN 107849
InChIKeySHNUBALDGXWUJI-UHFFFAOYSA-N
LogP0.11
CAS DataBase Reference586-98-1(CAS DataBase Reference)
NIST Chemistry ReferencePiconol(586-98-1)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 26-36-37/39
WGK Germany 3
RTECS UT4689000
3-8
Hazard Note Irritant/Keep Cold/Hygroscopic
HazardClass IRRITANT, HYGROSCOPIC, KEEP COLD
HS Code 29333999
MSDS Information
ProviderLanguage
2-(Hydroxymethyl)pyridine English
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2-(Hydroxymethyl)pyridine Usage And Synthesis
Chemical PropertiesCLEAR COLORLESS TO YELLOW OR BROWN LIQUID
Usesdecongestant
UsesA pyridylalcohol with hypoglycemic activity and potential apoptotic effect in human leukemia cells.
Uses2-Pyridinemethanol is used as a pyridylalcohol with hypoglycemic activity.
PreparationThe preparation of 2-(Hydroxymethyl)pyridine is as follows:NaOH (0.5 g, 12.5 mmol), Al2O3 (2.0 g, 19.6 mmol), aldehyde 1f-g (2 mmol) and H2O (400 μL) were grinded in a mortar. Next, the paste were placed in a glass 10 mL pressure vials and reaction was carried out in microwave reactor: standard mode (200 W), 100 °C, 2 min. After that, reaction mixture was extracted with DCM (2 × 20 mL). Organic layer was evaporated under reduce pressure yielding 2f-g. Solid residue was washed by water (2 × 15 mL). Aqueous phase was acidify with 1N HCl to pH 5.5 and centrifuged. After that aqueous layer was pour down and precipitate was lyophilisated. Products 3f-g were obtained as white solids.

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DefinitionChEBI: 2-Pyridinylmethanol is a member of pyridines.
Sulfasalazine 2-Hydroxymethylmorpholine 2-Hydrazinopyridine 2-Chloro-3-cyanopyridine Trimethylolpropane 4-Methylpyridine 2,3-Pyridinedicarboxylic acid Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 2,3-Pyridinedicarboxylic anhydride Azamethiphos Ethyl picolinate 3-(HYDROXYMETHYL)PYRIDINE,3-Hydroxymethyl pyridine (3-Pyridine methanol),3-(HYDROXYMETHYL)-PYRIDINE 97% (GC) 2,6-Lutidine 2,4,6-Collidine 2,4-Pyridinedicarboxylic acid 3-Hydroxypicolinic acid Pyridine PICOLINIC ACID N-OXIDE

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