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| | 5-Amino-4,6-dichloropyrimidine Basic information |
| Product Name: | 5-Amino-4,6-dichloropyrimidine | | Synonyms: | 4,6-DICHLORO-5-PYRIMIDINAMINE;4,6-DICHLOROPYRIMIDIN-5-AMINE;4,6-DICHLOROPYRIMIDIN-5-YLAMINE;AKOS 91433;5-PYRIMIDINAMINE, 4,6-DICHLORO-;4,6-Dichloro-5-aminopyrimidine;4,6-dichloro-5-pyrimidinamin;5-AMINO-4,6-DICHLOROPYFIMIDINE | | CAS: | 5413-85-4 | | MF: | C4H3Cl2N3 | | MW: | 163.99 | | EINECS: | 226-503-7 | | Product Categories: | Bases & Related Reagents;Heterocycles;Nucleotides;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines, Pyrimidines, Purines and Pteredines;Pyrimidine;Pyrimidines;Heterocyclic Compounds;PyrimidinesHeterocyclic Building Blocks;Aromatics;Heterocycle-Pyrimidine series;bc0001 | | Mol File: | 5413-85-4.mol |  |
| | 5-Amino-4,6-dichloropyrimidine Chemical Properties |
| | 5-Amino-4,6-dichloropyrimidine Usage And Synthesis |
| Chemical Properties | Yellowish-brown crystals or powder | | Uses | An intermediate in the production of many biological inhibitors. | | Uses | 5-Amino-4,6-dichloropyrimidine was used in the synthesis of:
- oxepane ring containing monocyclic, conformationally restricted bicyclic and spirocyclic nucleosides
- conformationally locked bicyclo[2.2.1]heptane/oxa-bicyclo[3.2.1]octane nucleosides
- N(7)-substituted purines
- chiral derivatives of (+)-erythro-9-(2-hydroxy-3-nonyl)adenine
- 9-alkyl-6-substituted-purine analogs, potent anticonvulsant agents
- pyrimido-oxazepines in a three-step process with microwave heating at 150°C
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| | 5-Amino-4,6-dichloropyrimidine Preparation Products And Raw materials |
| Raw materials | Ethyl acetate-->Nitric acid-->Phosphorus oxychloride-->Hexane-->Trifluoroacetic acid-->Stannous chloride dihydrate-->N,N-Diisopropylethylamine-->4,6-Dihydroxypyrimidine | | Preparation Products | 4,5-Diaminopyrimidine-->5-Pyrimidinamine, 1,4,5,6-tetrahydro--->2-(5-AMINO-6-CHLORO-PYRIMIDIN-4-YLAMINO)-ETHANOL-->6-CHLORO-N4-(4-CHLOROPHENYL)-4,5-PYRIMIDINEDIAMINE-->4-(5-AMINO-6-CHLORO-4-PYRIMIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER-->6-chloro-N4-ethylpyrimidine-4,5-diamine-->(R)-1-((5-aMino-6-chloropyriMidin-4-yl)aMino)propan-2-ol-->4-CHLORO-6-HYDRAZINO-PYRIMIDIN-5-YLAMINE |
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