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| | Methyltrienolone Basic information |
| | Methyltrienolone Chemical Properties |
| Melting point | 170° | | alpha | D20 -58.7° (c = 0.5 in ethanol) | | Boiling point | 485.9±45.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥10mg/mL | | pka | 14.79±0.40(Predicted) | | form | powder | | color | light yellow to yellow | | optical activity | [α]/D -48 to -68° | | InChI | InChI=1/C19H24O2/c1-18-9-7-15-14-6-4-13(20)11-12(14)3-5-16(15)17(18)8-10-19(18,2)21/h7,9,11,16-17,21H,3-6,8,10H2,1-2H3/t16-,17+,18+,19+/s3 | | InChIKey | CCCIJQPRIXGQOE-XWSJACJDSA-N | | SMILES | [C@@]12([H])CC[C@@](O)(C)[C@@]1(C)C=CC1=C3CCC(=O)C=C3CC[C@@]21[H] |&1:0,4,7,21,r| | | CAS DataBase Reference | 965-93-5(CAS DataBase Reference) |
| WGK Germany | 3 | | DEA Controlled Substances | CSCN: 4000
CSA SCH: Schedule III
NARC: No |
| | Methyltrienolone Usage And Synthesis |
| Description | Methyltrienolone, also called metribolone, is an orally active anabolic-androgen steroid being a 17α-alkylated nandrolone (19-nortestosterone) derivative. It is not sold as a prescription drug or a dietary supplement due to its strong androgenic side effects and liver toxicity. However, it is often used as the reference point for in vitro biological activity for biochemical studies. It can bind strongly to the androgen receptor and can be used as an affinity label of the androgen receptor in the prostate and prostatic tumors. | | Chemical Properties | Pale Yellow Solid | | Uses | Methyltrienolone is a synthetic derivative of testosterone that is used in the medical field as an androgen and anabolic agent. It has been used to treat breast cancer, prostate cancer, and other cancers that are sensitive to hormones. | | Definition | ChEBI: Methyltrienolone, also known as 7beta-hydroxy-17-methylestra-4,9,11-trien-3-one, is a synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors. It has a role as an androgen. It is an anabolic androgenic steroid, a 17beta-hydroxy steroid and a 3-oxo steroid. It derives from a hydride of an estrane. | | Biochem/physiol Actions | Androgen receptors (ARs) are nuclear hormone receptors/transcription factors. R1881, also known as methyltrienolone, is a synthetic androgen. It is the gold standard AR agonist. | | References | https://en.wikipedia.org/wiki/Metribolone
https://www.drugbank.ca/drugs/DB02998
https://pubchem.ncbi.nlm.nih.gov/compound/Methyltrienolone
Kazlauskas R. (2010) Designer Steroids. In: Thieme D., Hemmersbach P. (eds) Doping in Sports: Biochemical Principles, Effects and Analysis. Handbook of Experimental Pharmacology, vol 195. Springer, Berlin, Heidelberg
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| | Methyltrienolone Preparation Products And Raw materials |
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