ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Leucine derivatives Boc-N-methyl-L-leucine

Boc-N-methyl-L-leucine

Boc-N-methyl-L-leucine Basic information
Product Name:Boc-N-methyl-L-leucine
Synonyms:N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE;N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE;N-ALPHA-T-BUTOXYCARBONYL-BETA-T-BUTYL-L-ALANINE;N-ALPHA-T-BUTOXYCARBONYL-GAMMA-METHYL-L-LEUCINE;N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE;N-ALPHA-T-BOC-N-ALPHA-METHYL-L-LEUCINE;BOC-BETA-TBU-ALANINE;BOC-BETA-TBU-ALA-OH
CAS:53363-89-6
MF:C12H23NO4
MW:245.32
EINECS:
Product Categories:amino acids;Amino Acid Derivatives;N-Methyl Amino Acids
Mol File:53363-89-6.mol
Boc-N-methyl-L-leucine Structure
Boc-N-methyl-L-leucine Chemical Properties
Melting point 55-60 °C
Boiling point 338.2±21.0 °C(Predicted)
density 1.053±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
pka4.04±0.21(Predicted)
optical activity[α]20/D 36±2°, c = 1% in methylene chloride
BRN 2373250
InChIKeyYXJFAOXATCRIKU-VIFPVBQESA-N
CAS DataBase Reference53363-89-6(CAS DataBase Reference)
Safety Information
WGK Germany 3
HS Code 2924 19 00
HazardClass IRRITANT
MSDS Information
Boc-N-methyl-L-leucine Usage And Synthesis
DescriptionBoc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.
UsesBoc-N-methyl-L-leucine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.
Referenceshttps://en.wikipedia.org/wiki/Tert-Butyloxycarbonyl_protecting_group
http://pubs.acs.org/doi/abs/10.1021/cr030024z?src=recsys&journalCode=chreay
Boc-N-methyl-L-leucine Preparation Products And Raw materials
Raw materialsBOC-L-Leucine-->Iodomethane
Boc-Aib-OH Methylparaben Methyl Bensulfuron methyl Boc-N-methyl-L-leucine Parathion-methyl N-Carbobenzyloxyglycine BOC-L-Leucine BOC-GLY-LEU-OH N-tert-Butoxycarbonyl-L-leucine N-carboxylic anhydride Kresoxim-methyl Thiophanate-methyl FMOC-ARG(ME,PBF)-OH Methyl acrylate L-Leucine Methyl bromide N-CARBOBENZOXY-DL-LEUCINE L-tert-Leucine
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