ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatic acids 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID

5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID

5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Basic information
Product Name:5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
Synonyms:5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID;AKOS B000092;2-Thiophenecarboxylic acid, 5-chloro-;Chlorothiophene-2-carboxy;5-Chlorothiophene-2-carboxylic Acid, 97+%;Rivaroxaban Impurity 40;TIMTEC-BB SBB003937;RARECHEM AL BE 0303
CAS:24065-33-6
MF:C5H3ClO2S
MW:162.59
EINECS:000-000-0
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds;Intermediates;Thiophene&Benzothiophene;Miscellaneous;Halogenated Heterocycles;Heterocyclic Building Blocks;Thiophenes;ThiophenesBuilding Blocks;Heterocycle-oher series;Intermediate of Rivaroxaban;Heterocycles;bc0001;24065-33-6
Mol File:24065-33-6.mol
5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Structure
5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Chemical Properties
Melting point 154-158 °C(lit.)
Boiling point 287.0±20.0 °C(Predicted)
density 1.466 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka3.32±0.10(Predicted)
form Powder
color Cream-yellow
BRN 118361
InChIInChI=1S/C5H3ClO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8)
InChIKeyQZLSBOVWPHXCLT-UHFFFAOYSA-N
SMILESC1(C(O)=O)SC(Cl)=CC=1
CAS DataBase Reference24065-33-6(CAS DataBase Reference)
NIST Chemistry Reference5-Chloro-2-thiophenecarboxylic acid(24065-33-6)
Safety Information
Hazard Codes Xi
Risk Statements 36-43-36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS XM8400000
HazardClass IRRITANT
HS Code 29349990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Usage And Synthesis
Chemical PropertiesWhite to light yellow crystal powder
Uses5-Chlorothiophene-2-carboxylic acid can be used in the synthesis of the following:
  • rivaroxaban, an oxazolidinone derivative used in the treatment of thromboembolic disorders
  • 5-chloro-4-nitrothiophene-2-carboxylic acid, which can be used in the synthesis of thieno[2,3-b][1,4]thiapezine-5-ones
UsesA metabolite of Rivaroxaban (R538000).
METHYL 5-CHLORO-3-[(2,3,3-TRICHLOROACRYLOYL)OXY]THIOPHENE-2-CARBOXYLATE RARECHEM AL BF 0303 5-Chlorothiophene-2-carboxylic acid ethyl ester AKOS 2108 AKOS 93395 2,3-Dihydro-3-oxo-2-chlorothiophene-2-carboxylic acid methyl ester AKOS 92293 AKOS 93408 AKOS 206-10 AKOS 93410 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER AKOS 90039 5-CHLORO-3-(METHOXYCARBONYLMETHYLMETHYLSULFAMOYL)THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID AKOS 93409 AKOS 91249 4,5-DICHLOROTHIOPHENE-2-CARBOXYLIC ACID AKOS 92473
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