N-NITROSOMORPHOLINE

N-NITROSOMORPHOLINE Basic information

Product Name:	N-NITROSOMORPHOLINE
Synonyms:	4-nitroso-morpholin;4-Nitrosomorpholine;Morpholine, N-nitroso-;Morpholine,4-nitroso-;N-Nitrosomorpholine 100mg [59-89-2];NSC 139;nci-c02164;nitrosomorpholineisopac
CAS:	59-89-2
MF:	C4H8N2O2
MW:	116.12
EINECS:	627-564-6
Product Categories:	Mutagenesis Research Chemicals;Nitric Oxide Reagents;Nitrosamine;pharmacetical;Alpha Sort;N;NA - NI;N-OAlphabetic;Volatiles/ Semivolatiles
Mol File:	59-89-2.mol

N-NITROSOMORPHOLINE Chemical Properties

Melting point	29°C
Boiling point	225℃
density	1.2829 (rough estimate)
refractive index	1.4880 (estimate)
Fp	29 °C
storage temp.	2-8°C
Water Solubility	Completely soluble in water
solubility	DMSO : 100 mg/mL (861.18 mM)
form	neat
pka	-5.72±0.20(Predicted)
color	White or Colorless to Yellow
Merck	14,6640
Stability:	Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents. Refrigerate, store in the dark.
IARC	2B (Vol. 17, Sup 7) 1987
EPA Substance Registry System	N-Nitrosomorpholine (59-89-2)

Safety Information

Hazard Codes	Xn,T,F
Risk Statements	22-40-39/23/24/25-23/24/25-11
Safety Statements	36/37-45-16-7
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
RTECS	QE7525000
HS Code	2934.99.9001
HazardClass	6.1(b)
PackingGroup	III
Hazardous Substances Data	59-89-2(Hazardous Substances Data)
Toxicity	LD50 orally in rats: 282 mg/kg (Druckrey)

MSDS Information

Provider	Language
SigmaAldrich	English

N-NITROSOMORPHOLINE Usage And Synthesis

Chemical Properties	yellow crystals or gold liquid
Uses	N-Nitrosomorpholine, a frequently used genotoxic model carcinogen. Toxicogenomic analysis of N-Nitrosomorpholine induced changes in rat liver.
Uses	Solvent for polyacrylonitrile; present during rubber manufacturing
Definition	ChEBI: A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.
Synthesis Reference(s)	Synthetic Communications, 22, p. 2607, 1992 DOI: 10.1080/00397919208021659
General Description	Yellow crystals. Golden liquid with many crystals at 68°F.
Air & Water Reactions	Water soluble.
Reactivity Profile	N-NITROSOMORPHOLINE is incompatible with strong oxidizing agents .
Health Hazard	ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSOMORPHOLINE emits toxic fumes of nitrogen oxides.
Fire Hazard	Flash point data for N-NITROSOMORPHOLINE are not available; however, N-NITROSOMORPHOLINE is probably combustible.
Biochem/physiol Actions	Tumor initiator in rodent liver, trachea, nasal cavity, esophagus, kidney, lung, and thyroid.
Safety Profile	Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Human mutation data reported. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.
Carcinogenicity	N-Nitrosomorpholine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

N-NITROSOMORPHOLINE Preparation Products And Raw materials

Preparation Products

N-NitrosoMorpholine-d4

N-Nitrosodibutylamine 4-Acryloylmorpholine CIS-N-NITROSO-2,6-DIMETHYLMORPHOLINE N-NITROSOMORPHOLINE-D8 Morpholine, 4-nitro- (6CI, 7CI, 8CI, 9CI) N-NITROSOMORPHOLINE SOLUTION 100UG/ML IN METHANOL 1ML 5-pentyl-N-nitrosomorpholine N-NITROSOMORPHOLINE 4-NITROSO-MORPHOLIN-3-OL N-nitroso-2-methoxy-2,6-dimethylmorpholine 2-HYDROXY-N-NITROSOMORPHOLINE 3,5-Dimethyl-4-nitrosomorpholine N-NITROSOMORPHOLINE SOLUTION 100UG/ML IN METHANOL 5X1ML 4-NITROSO-MORPHOLINE-3-CARBOXYLIC ACID N-NITROSOMORPHOLINE SOLUTION 100UG/ML IN METHANOL 5ML MOLSIDOMINE IMP. B (PHARMEUROPA): 4-NITROSOMORPHOLINE N-nitroso-2-hydroxymorpholine 2,6-DIMETHYL-N-NITROSOMORPHOLINE,2,6-Dimethyl-4-nitrosomorpholine

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