ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound 4-bromoisoindolin-1-one

4-bromoisoindolin-1-one

4-bromoisoindolin-1-one Basic information
Product Name:4-bromoisoindolin-1-one
Synonyms:4-bromoisoindolin-1-one;4-BroMoisoindoline-1-one;1H-Isoindol-1-one,4-broMo-2 3-dihydro-;4-broMo-2,3-dihydro-1H-isoindol-1-one;4-Bromoisoindolin-1-one 97%;Ethanone,1-[3,6-dihydroxy-2-methoxy-7-(phenylmethoxy)phenyl]-;4-Bromo-1-isoindolinone;4-Bromoisoindolin-1-one?New
CAS:337536-15-9
MF:C8H6BrNO
MW:212.04
EINECS:
Product Categories:
Mol File:337536-15-9.mol
4-bromoisoindolin-1-one Structure
4-bromoisoindolin-1-one Chemical Properties
Boiling point 448.9±45.0 °C(Predicted)
density 1.666
storage temp. Sealed in dry,Room Temperature
pka13.69±0.20(Predicted)
form solid
color Off-white to light yellow
Safety Information
HS Code 2933790090
MSDS Information
4-bromoisoindolin-1-one Usage And Synthesis
Uses4-bromoisoindolin-1-one can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
SynthesisSynthesis_337536-15-9
To a solution of the 3-bromo-2-bromomethyl-benzoic acid methyl ester (2.74 g, 8.88 [MMOL)] in tetrahydrofuran (70 [ML)] at [0??C] was added 30 percent aq. ammonia (10 ml) and the mixture stirred at room temperature under nitrogen for 18 hours. The solvent was removed by evaporation under reduced pressure. The white residue was partitioned between ethyl acetate (50 mi) and 2M citric acid (50 [ML).] The ethyl acetate was dried magnesium sulfate, filtered and solvent removed by evaporation under reduced pressure. The orange oil was dissolved in minimum [DICHLOROMETHANE] and purified by flash chromatography on silica gel eluting with a solvent gradient of [DICHOROMETHANE/METHANOL] (9: 1) to give the title compound (1.5 g, 80 percent) as a white solid.
methyl 4-bromoquinoline-8-carboxylate 6-AMino-2,3-dihydroisoindol-1-one 4-nitroisoindolin-1-one 5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE 6-NITRO-ISOINDOLIN-1-ONE 6-bromoisoindolin-1-one AURORA 17476 3,4,5,6-TETRABROMOPHTHALIMIDE 4-bromoisoindolin-1-one AURORA 17478 AURORA 17475 AURORA 17474 AURORA 17308 4-BROMO-6,7-DIMETHOXY-ISOINDOLIN-1-ONE 4,5,6,7-TETRABROMO-2-(OXIRAN-2-YLMETHYL)ISOINDOLINE-1,3-DIONE 1,2-Bis(tetrabromophthalimido) ethane AURORA 17477 N,N'-(methylenedi-p-phenylene)bis[3,4,5,6,-tetrabromophthalimide]
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