ChemicalBook Product Catalog Analytical Chemistry Standard Standard Substance 1'-HYDROXYMIDAZOLAM

1'-HYDROXYMIDAZOLAM

1'-HYDROXYMIDAZOLAM Basic information
Product Name:1'-HYDROXYMIDAZOLAM
Synonyms:8-CHLORO-6-(2-FLUOROPHENYL)-1-HYDROXYMETHYL-4H-IMIDAZO[1,5A][1,4]BENZODIAZEPINE;A-HYDROXYMIDAZOLAM;RO 21-6347;1-HYDROXY MIDAZOLAM;1'-HYDROXYMIDAZOLAM;1Hydroxymidazolame;alpha-Hydroxymidazolame;4H-Imidazo1,5-a1,4benzodiazepine-1-methanol, 8-chloro-6-(2-fluorophenyl)-
CAS:59468-90-5
MF:C18H13ClFN3O
MW:341.77
EINECS:200-659-6
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Metabolites
Mol File:59468-90-5.mol
1'-HYDROXYMIDAZOLAM Structure
1'-HYDROXYMIDAZOLAM Chemical Properties
Melting point 264-266oC
Boiling point 540.6±60.0 °C(Predicted)
density 1.43±0.1 g/cm3(Predicted)
Fp 9℃
storage temp. 2-8°C
solubility DMF: 2 mg/ml; DMSO: 1 mg/ml
form A crystalline solid
pka13.59±0.10(Predicted)
color white or off-white
Safety Information
Hazard Codes F,T
Risk Statements 11-23/24/25-39/23/24/25
Safety Statements 7-16-36/37-45
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
1'-HYDROXYMIDAZOLAM Usage And Synthesis
Description1''-hydroxy Midazolam is the major metabolite of the anesthetic, midazolam. It is produced rapidly by the actions of hepatic cytochrome P450 3A and has been shown to be equipotent to midazolam.
Chemical PropertiesWhite Solid
UsesA metabolite of Midazolam (M343000).
UsesCYP3A4 metabolite of midazolam
DefinitionChEBI: 1-hydroxymidazolam is an imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam. It has a role as a drug metabolite, a human blood serum metabolite and a human urinary metabolite. It is an imidazobenzodiazepine, an organochlorine compound, a member of monofluorobenzenes and an aromatic primary alcohol. It is functionally related to a midazolam.
1'-HYDROXYMIDAZOLAM Preparation Products And Raw materials
Bupropion ALPHA-HYDROXYMIDAZOLAM UNLABELED 100 UG/ML IN METHANOL Midazolam 1-HYDROXY MIDAZOLAM-13C2 4-HYDROXYMIDAZOLAM 1'-HYDROXYMIDAZOLAM Midazolam a-Hydroxymidazolam-13C3, 8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine-13C3,,1'-HYDROXYMIDAZOLAM-13C3 1-ACETOXYMETHYL-8-CHLORO-6-(2-FLUOROPHENYL)-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE 5-OXIDE 1'-HYDROXYMIDAZOLAM-?-D-GLUCURONIDE,1Hydroxymidazolam-b-D-glucuronide 4-HYDROXYMIDAZOLAM ALPHA-HYDROXYMIDAZOLAM-D4 4-Hydroxymidazolam b-D-Glucuronide,4-Hydroxymidazolam -D-Glucuronide 1-ACETOXYMETHYL-8-CHLORO-6-(2-FLUOROPHENYL)-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE
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