ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Arginine derivatives NG-MONOMETHYL-L-ARGININE ACETATE

NG-MONOMETHYL-L-ARGININE ACETATE

NG-MONOMETHYL-L-ARGININE ACETATE Basic information
Product Name:NG-MONOMETHYL-L-ARGININE ACETATE
Synonyms:NG-Methyl-L-arginine acetate salt >=95% (HPLC);Ngamma-methyl-L-arginine acetate;L-NMMA, NG-Monomethyl-L-arginine acetate salt, Nω-Methyl-L-arginine acetate salt, N5-(Methylamidino)-L-ornithine acetate salt;N-Monomethyl-L-arginine;Nα-Methyl-L-arginine;NG-Monomethyl-L-arginine monoacetate,99%;NG-Monomethyl-L-arginine acetate salt;L-NG-Monomethylarginine, Acetate Salt (L-NMMA)
CAS:53308-83-1
MF:C9H20N4O4
MW:248.28
EINECS:
Product Categories:Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Nitric Oxide Reagents;Signalling
Mol File:53308-83-1.mol
NG-MONOMETHYL-L-ARGININE ACETATE Structure
NG-MONOMETHYL-L-ARGININE ACETATE Chemical Properties
Melting point 180-190 °C
alpha D22 +9.5° (c = 0.10 in water)
Boiling point 391.35°C (rough estimate)
density 1.2162 (rough estimate)
refractive index 1.6300 (estimate)
storage temp. 2-8°C
solubility H2O: 1 mg/mL, clear, colorless
form Powder
color White to Off-white
Water Solubility Soluble in water (50 mM)
BRN 6674255
Stability:Store at - 5°C; Desiccate Recommended
InChIKeyIKPNWIGTWUZCKM-JEDNCBNOSA-N
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 29252900
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
NG-MONOMETHYL-L-ARGININE ACETATE Usage And Synthesis
DescriptionL-NMMA is the archetypal competitive NOS inhibitor to which other inhibitors are often compared. It is a relatively non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 μM, respectively.
Chemical PropertiesWhite Crystalline Powder
UsesNitric oxide synthase inhibitor
UsesReagent to inhibit nitric oxide production in biological systems.
UsesA potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells
Biological ActivityCompetitive, irreversible inhibitor of all three NOS isoforms.
Biochem/physiol ActionsNG-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.
storageRoom temperature
NG-MONOMETHYL-L-ARGININE ACETATE Preparation Products And Raw materials
L-N5-(1-IMINOETHYL)ORNITHINE*HYDROCHLORI DE NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE 7-NINA IroMycin A AMINOGUANIDINE HEMISULFATE Aminoguanidine bicarbonate L-NAA HCL L-THIOCITRULLINE DIHYDROCHLORIDE L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE NG-MONOMETHYL-D-ARGININE ACETATE L-Ornithine NG-MONOMETHYL-L-ARGININE ACETATE L-Arginine acetate BRADYKININ DIACETATE HEPTAHYDRATE NG-MONOETHYL-L-ARGININE, MONOACETATE SALT L-NG-MONOMETHYL ARGININE CITRATE ARGININOSUCCINIC ACID DISODIUM SALT NG-MONOMETHYL-D-ARGININE ACETATE
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