| Chemical Properties | White Solid |
| Originator | Bromisovalum,Linhai Duqiao Fine
Chemical Factory |
| Uses | 2-Bromo-3-methylbutyrylurea is a hypnotic and sedative drug marketed over the counter in Asian under various brand names. |
| Definition | ChEBI: An N-acylurea that is urea in which one of the hydrogens is replaced by a 2-bromo-3-methybutanoyl group. |
| Manufacturing Process | A mixture of 2 kg 2-bromoisovalerylbromide and 1 kg dry urea is heated at
70°C. Then to the reaction mixture is added sodium hydrogen carbonate. 2-
Bromo-3-methylbutyrylurea is recrystallized from toluene or water, melting
point 149°C. |
| Brand name | Bromural (Knoll). |
| Therapeutic Function | Sedative, Hypnotic |
| World Health Organization (WHO) | Bromisoval is a monureide sedative of long standing. It remains
available in several countries. However, it releases the bromide ion and prolonged
usage can result in chronic bromide accumulation and intoxication. |
| Safety Profile | Moderately toxic by
ingestion. Human systemic effects by
ingestion: nausea or vomiting, and coma. A
sedative and hypnotic agent. When heated
to decomposition it emits very toxic fumes
of Brand NOx |
| Purification Methods | Crystallise it from aqueous EtOH or toluene, and dry it in air. [Beilstein 3 H 63, 3 I 29, 3 II 51, 3 III 123, 3 IV 117.] |
