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| | brusatol Basic information |
| Product Name: | brusatol | | Synonyms: | 13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicras-3-en-21-oic acid methyl ester;13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicrasa-3-ene-21-oic acid methyl ester;methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-1,4,5,6a,7,7a,10,11,11a,11b-decahydro-2H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3(3aH)-carboxylate;Picras-3-en-21-oicacid,13,20-epoxy-3,11,12-trihydroxy-15-[(3-Methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-,Methyl ester, (11b,12a,15b)-;NSC 172924;Yatansin;Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-;Brustaol | | CAS: | 14907-98-3 | | MF: | C26H32O11 | | MW: | 520.53 | | EINECS: | | | Product Categories: | | | Mol File: | 14907-98-3.mol |  |
| | brusatol Chemical Properties |
| Boiling point | 724.3±60.0 °C(Predicted) | | density | 1.46±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | -20°C | | solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | | pka | 8.81±0.70(Predicted) | | form | powder | | color | white to beige | | optical activity | [α]/D +35 to +44°, c = 0.5 in acetone | | LogP | 0.393 (est) |
| | brusatol Usage And Synthesis |
| Uses | Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury. | | Definition | ChEBI: Brusatol is a triterpenoid. | | Biochem/physiol Actions | Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function. |
| | brusatol Preparation Products And Raw materials |
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