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N-methylisatoic anhydride

N-methylisatoic anhydride Basic information
Product Name:N-methylisatoic anhydride
Synonyms:N-methyl isotoic anhydride;Isatoic anhydride, N-Methyl-;N-Methylisatioc anhydride;1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione;1-Methyl-1,2-dihydro-4H-3,1-benzoxazine-2,4-dione;1-Methyl-1H-3,1-benzoxazine-2,4-dione;1-Methyl-4H-3,1-benzoxazine-2(1H),4-dione;N-Methylisatoic anhydride,90%,tech.
CAS:10328-92-4
MF:C9H7NO3
MW:177.16
EINECS:233-714-8
Product Categories:Monomers;Polymer Science;pharmacetical;Anhydride Monomers
Mol File:10328-92-4.mol
N-methylisatoic anhydride Structure
N-methylisatoic anhydride Chemical Properties
Melting point 165 °C (dec.)(lit.)
Boiling point 309.06°C (rough estimate)
density 1.3312 (rough estimate)
vapor density 6.1 (vs air)
refractive index 1.5200 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in DMSO
pka-2.24±0.20(Predicted)
Sensitive Moisture Sensitive
CAS DataBase Reference10328-92-4(CAS DataBase Reference)
EPA Substance Registry System2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl- (10328-92-4)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
WGK Germany 3
RTECS DM3140000
TSCA Yes
HS Code 2934.99.4400
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
N-methylisatoic anhydride Usage And Synthesis
Chemical Propertiesbrownish chunks
UsesN-Methylisatoic anhydride is a 2'-OH selective acylation agent of RNAs, and is widely used for resolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology.
DefinitionChEBI: N-methylisatoic anhydride is a 3,1-benzoxazin-1,4-dione having an N-methyl substituent.
ApplicationN-Methylisatoic anhydride was first condensed with ethanolamine to give N-(2-hydroxyethyl)-2-methylaminobenzamide. Cyclization of the latter with ethyl pyruvate gave quinazoline derivatives which, upon hydrolysis and dehydrative cyclization with l-methyl-2-chloropyridinium iodide, afforded the l,4-oxazines[3,4-]quinazoline.
N-methylisatoic anhydride Preparation Products And Raw materials
Preparation ProductsRoquinimex-->2-METHYLAMINO-N-PHENETHYL-BENZAMIDE
5-Chloro-N-methylisatoic anhydride N-METHYLISATOIC ANHYDRIDE POLYSTYRENE (100-200 MESH, 3 MMOL/G) 1-(1H,1H,2H,2H,3H,3H-PERFLUOROUNDECYL)-3,1-BENZOXAZINE-2,4(1H)-DIONE 1-(3,4-DICHLOROBENZYL)-2H-3,1-BENZOXAZINE-2,4(1H)-DIONE N-methylisatoic anhydride HUMAN MIA N-ALLYLISATOIC ANHYDRIDE 6-Methylisatoic anhydride MIA protein KG POA 5-METHYLISATOIC ANHYDRIDE 5-METHYLISATOIC ANHYDRIDE N-METHYLISATOIC ANHYDRIDE POLYSTYRENE HL 1-ISOPROPYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE 3-METHOXY-N-METHYLISATOIC ANHYDRIDE 7-FLUORO-2-METHYLISATOIC ANHYDRIDE AMILORIDE, 5-(N-METHYL-N-ISOBUTYL) (MIA) >97% EXTREMELY POTE,MIA N-BENZYLISATOIC ANHYDRIDE 5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
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