|
| | Gestrinone Basic information |
| Product Name: | Gestrinone | | Synonyms: | (8s,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;13-ETHYL-17ALPHA-HYDROXY-18,19-DINORPREGNA-4,9,11-TRIEN-20-YN-3-ONE;D-GESTRINONE;GESTRINONE;9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-19-dinorpregna-(17-alpha)-1;ethylnorgestrienone;gestrigone;r-2323 | | CAS: | 16320-04-0 | | MF: | C21H24O2 | | MW: | 308.41 | | EINECS: | 685-143-2 | | Product Categories: | Hormone;Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids | | Mol File: | 16320-04-0.mol |  |
| | Gestrinone Chemical Properties |
| Melting point | 150-152°C | | alpha | D20 +84.6° (c = 0.41 in methanol) | | Boiling point | 388.8°C (rough estimate) | | density | 1.1040 (rough estimate) | | refractive index | 1.4900 (estimate) | | storage temp. | -20°C Freezer | | solubility | DMF:20.0(Max Conc. mg/mL);64.85(Max Conc. mM)
DMSO:35.0(Max Conc. mg/mL);113.48(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);64.85(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:5):0.25(Max Conc. mg/mL);81.06(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.24(Max Conc. mM) | | form | A crystalline solid | | pka | 12.76±0.40(Predicted) | | Merck | 14,4415 | | Stability: | Hygroscopic | | CAS DataBase Reference | 16320-04-0(CAS DataBase Reference) |
| RTECS | JF7964000 | | Toxicity | mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)GASTROINTESTINAL: OTHER CHANGES,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 701, 1988. |
| Provider | Language |
|
(8S,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
| English |
| | Gestrinone Usage And Synthesis |
| Description | Gestrinone is a synthetic steroid with antiprogesterone and antiestrogenic activities.
It is reported to be useful in the treatment of endometriosis and uterine leiom yomas. | | Chemical Properties | Light Yellow Solid | | Originator | Roussel UCLAF (France) | | Uses | Steroidal antiestrogen, antiprogestogen, analog of Norgestrienone. Antigonadotropin.
Controlled substance. | | Definition | ChEBI: Gestrinone is an oxo steroid. | | Brand name | DIMETROSE |
| | Gestrinone Preparation Products And Raw materials |
|
