|
| Product Name: | Tapinarof | | Synonyms: | 3,5-Dihydroxy-4-isopropylstilbene;(E)-2-(1-Methylethyl)-5-(2-phenylethenyl)-1,3-benzenediol;2-(1-methylethyl)-5-[(E)-2-phenylethenyl]benzene-1,3-diol;3,5-Dihydroxy-4-isopropyl-trans-stilbene;GSK2894512);Tapinarof (WBI 1001;WB-1001;WBI-1001 | | CAS: | 79338-84-4 | | MF: | C17H18O2 | | MW: | 254.32 | | EINECS: | 1312995-182-4 | | Product Categories: | | | Mol File: | 79338-84-4.mol |  |
| | Tapinarof Chemical Properties |
| Melting point | 140 - 142°C | | Boiling point | 431.8±20.0 °C(Predicted) | | density | 1.158 | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 9.86±0.15(Predicted) | | form | Solid | | color | Pale Brown to Light Brown |
| | Tapinarof Usage And Synthesis |
| Description | Tapinarof is a small molecule stilbene compound, with a chemical name of 3,5-Dihydroxy-4-isopropylstilbene,which was originally isolated from the metabolite of photorhabdus iuminescence, a soil nematode (Heterorhabditis sp.), and has been synthesized artificially. | | Biological activity | Tapinarof(GSK2894512) is a natural agonist of aryl hydrocarbon receptor (AhR) that induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) with EC50 of 0.16 nM. Benvitimod induces apoptosis in CD4+ T cells in a dose-dependent manner with an IC50 value of 5.2 μM. | | Uses | Clinically, tapinarof was first used in the treatment of psoriasis and atopic dermatitis. Clinical trials conducted abroad have shown that Benzenemod cream has good efficacy and safety on atopic dermatitis and psoriasis. In China, as a class 1.1 new drug, Benzenemod cream has undergone phase I-II clinical trials, and the results show that it has good efficacy and safety for plaque psoriasis. |
| | Tapinarof Preparation Products And Raw materials |
|
