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| | Methylthiouracil Basic information |
| | Methylthiouracil Chemical Properties |
| Melting point | ~330 °C (dec.)(lit.) | | density | 1.291 (estimate) | | refractive index | 1.6430 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Heated), Methanol (Slightly, Heated) | | form | Liquid | | pka | pKa 8.2 (Uncertain) | | color | Clear colorless to yellow | | Water Solubility | INSOLUBLE | | Merck | 14,6128 | | BRN | 115648 | | Stability: | Incompatible with strong oxidizing agents, iodine, metals. | | InChIKey | HWGBHCRJGXAGEU-UHFFFAOYSA-N | | CAS DataBase Reference | 56-04-2(CAS DataBase Reference) | | IARC | 2B (Vol. Sup 7, 79) 2001 | | NIST Chemistry Reference | 6-Methyl-2-thiouracil(56-04-2) | | EPA Substance Registry System | Methylthiouracil (56-04-2) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-40 | | Safety Statements | 36/37-45 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | RTECS | YR0875000 | | Hazard Note | Irritant/Possible Carcinogen | | TSCA | Yes | | HS Code | 29335995 | | Hazardous Substances Data | 56-04-2(Hazardous Substances Data) | | Toxicity | MLD in rabbits (mg/kg): 2486 orally (Simon) |
| | Methylthiouracil Usage And Synthesis |
| Chemical Properties | white powder | | Uses | antithyroid agent | | Uses | 6-?Methyl-?2-?thiouracil is a derivative of methylthiouracil (M330710), a competitive inhibitor of Nitric Oxide Synthase (NOS). Potential anti-inflammatory agent. | | Definition | ChEBI: Methylthiouracil is a pyrimidone. | | General Description | White crystalline powder with an odor of onions and a bitter taste. A saturated aqueous solution is neutral or slightly acidic. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | Methylthiouracil reacts with strong oxidizing agents. Forms complexes with metals and is oxidized by iodine and other sulfhydryl oxidizing agents . | | Fire Hazard | Flash point data for Methylthiouracil are not available. Methylthiouracil is probably combustible. | | Safety Profile | Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, tumorigenic, and teratogenic
data. Poison by intraperitoneal route.
Moderately toxic by ingestion. Human
teratogenic and reproductive effects by an
unspecified route: developmental
abnormalities of the endocrine system and
effects on newborn including neonatal
measures or effects. Experimental
reproductive effects. Used to treat
hyperthyroidism. When heated to
decomposition it emits very toxic fumes of
NOx and SOx. | | Purification Methods | Crystallise the thiouracil from a large volume of H2O. Purify it further by dissolving in base, adding charcoal, filtering and acidifying with AcOH. Suspend the wet solid (ca 100g) in boiling H2O (1L), stir and add AcOH (20mL), stir and refrigerate. Collect the product, wash it with cold H2O (4 x 200mL), drain it for several hours then place it in an oven at 70o to constant weight. [IR: Short & Thompson J Chem Soc 168 1952, Foster & Snyder Org Synth Coll Vol IV 638 1063, Beilstein 24 III/IV 1289.] |
| | Methylthiouracil Preparation Products And Raw materials |
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