ChemicalBook Product Catalog Organic Chemistry Hydrocarbons and derivatives Hydrocarbon sulfonate 2-Methylbenzene-1-sulfonamide

2-Methylbenzene-1-sulfonamide

2-Methylbenzene-1-sulfonamide Basic information
Product Name:2-Methylbenzene-1-sulfonamide
Synonyms:4-TOLUENESULFONIC ACID AMIDE;2-METHYLBENZENE-1-SULFONAMIDE;2-TOLUENESULFONAMIDE;TOLUENE-4-SULPHONAMIDE;TOLUENE-2-SULFONAMIDE;2-methylbenzenesulphonamide;2-tolylsulfonamide;methyl-2benzenesulfonamide
CAS:88-19-7
MF:C7H9NO2S
MW:171.22
EINECS:201-808-8
Product Categories:Pharmaceutical Intermediates;Aromatics, Impurities, Mutagenesis Research Chemicals, Sulfur & Selenium Compounds;Organics;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds;Intermediates;SULFONAMIDE
Mol File:88-19-7.mol
2-Methylbenzene-1-sulfonamide Structure
2-Methylbenzene-1-sulfonamide Chemical Properties
Melting point 156-158 °C (lit.)
Boiling point 221 °C
density 1.2495 (rough estimate)
vapor pressure 0-0.008Pa at 25℃
refractive index 1.6100 (estimate)
Fp 178°C
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Very Slightly, Heated)
form neat
pka10.17±0.60(Predicted)
color White to Off-White
Water Solubility Soluble in water (1.6 g/L at 25°C).
BRN 1102362
InChIKeyYCMLQMDWSXFTIF-UHFFFAOYSA-N
LogP0.6-0.9 at 20-25℃
CAS DataBase Reference88-19-7(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenesulfonamide, 2-methyl-(88-19-7)
EPA Substance Registry SystemBenzenesulfonamide, 2-methyl- (88-19-7)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36-40
Safety Statements 26-36/37
WGK Germany 1
RTECS XT5075000
TSCA Yes
HS Code 29350090
Hazardous Substances Data88-19-7(Hazardous Substances Data)
MSDS Information
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2-Methylbenzene-1-sulfonamide English
SigmaAldrich English
ACROS English
ALFA English
2-Methylbenzene-1-sulfonamide Usage And Synthesis
Chemical Properties2-Methylbenzene-1-sulfonamide is Colorless crystals. Soluble in alcohol; slightly soluble in water and ether. Combustible.
Useso-Toluenesulfonamide is a methylated sulfonamide and a major impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity.
UsesPlasticizer of thermosetting resin, as a raw material used in organic synthesis, preparation of nail polish, dyes, fluorescent pigments and coatings.
Uses2-Methylbenzene-1-sulfonamide is a methylated sulfonamide and a major Impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity.
General DescriptionPharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. o-Toluenesulfonamide is a major impurity in artificial sweetening substances containing saccharin.
Safety ProfileSuspected carcinogen with experimental tumorigenic data. Mildly toxic by ingestion. Experimental reproductive effects. Mutation data reported. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used as a chemical intermediate in the production of saccharin.
Purification MethodsCrystallise the amide from hot H2O (m 153o), then from EtOH or Et2O/pet ether. The N-o-toluenesulfonylphthalimide has m 182o (from EtOH). [Evans & Dehn J Am Chem Soc 51 3652 1929, Beilstein 11 H 86, 11 I 23, 11 II 39, 11 III 167, 11 IV 229.]
toluenesulphonamide,mixedisomer N-(2-hydroxyethyl)-N-(3-hydroxypropyl)-p-toluenesulphonamide 3-amino-5-chloro-4-methylbenzene-1-sulfonamide 1-(2,4,6-TRIISOPROPYLBENZENESULFONYL)-3-NITRO-1H-1,2,4-TRIAZOLE N-(2-NITROPHENYLTHIO)SACCHARIN, 95% 3-amino-5-chloro-N-(1,3-dimethyl-1H-pyrazol-5-yl)-4-methylbenzene-1-sulfonamide 3-amino-5-chloro-N-(3-methoxyphenyl)-4-methylbenzene-1-sulfonamide TRIFLUOROMETHANESULFONAMIDE 3-amino-5-chloro-N-(3-fluoro-4-methylphenyl)-4-methylbenzene-1-sulfonamide 3-amino-5-chloro-N-(2,3-dimethylphenyl)-4-methylbenzene-1-sulfonamide 3-amino-5-chloro-N-(1-methoxypropan-2-yl)-4-methylbenzene-1-sulfonamide 3-amino-5-chloro-N-(3,5-dichlorophenyl)-4-methylbenzene-1-sulfonamide ACID YELLOW 25 3-amino-5-chloro-N-(2-fluoro-4-methylphenyl)-4-methylbenzene-1-sulfonamide 3-amino-5-chloro-N-(2,5-dimethylphenyl)-4-methylbenzene-1-sulfonamide 3-amino-5-chloro-N-(3-chloro-2-methylphenyl)-4-methylbenzene-1-sulfonamide 3-amino-5-chloro-N-(3-ethoxypropyl)-4-methylbenzene-1-sulfonamide 1-(2,4,6-Triisopropylphenylsulfonyl)imidazole
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