GSK-3BETA INHIBITOR XII

GSK-3BETA INHIBITOR XII Basic information
Product Name:GSK-3BETA INHIBITOR XII
Synonyms:TWS119;GSK-3BETA INHIBITOR XII;3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL;CS-1924;TWS-119; TWS 119;CS-445;OTAVA-BB 7070707013;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate
CAS:601514-19-6
MF:C18H14N4O2
MW:318.33
EINECS:
Product Categories:Akt;mTOR;Inhibitors;PI3K
Mol File:601514-19-6.mol
GSK-3BETA INHIBITOR XII Structure
GSK-3BETA INHIBITOR XII Chemical Properties
Melting point 249 °C
density 1.42
storage temp. 2-8°C
solubility insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
form powder
pka8.99±0.10(Predicted)
color white to beige
Safety Information
MSDS Information
GSK-3BETA INHIBITOR XII Usage And Synthesis
UsesActs as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.
UsesTWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor.
DefinitionChEBI: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol is a member of pyrroles.
General DescriptionA cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM).
Biological ActivityInhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
Biochem/physiol ActionsTWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production.
targetGSK-3β
storageStore at +4°C
references[1] ding s, wu t y h, brinker a, et al. synthetic small molecules that control stem cell fate. proceedings of the national academy of sciences, 2003, 100(13): 7632-7637.
[2] wu t y h, ding s. applying chemical tools to the discovery of novel regenerative medicine. drug discovery today: technologies, 2006, 3(3): 255-260.
GSK-3BETA INHIBITOR XII Preparation Products And Raw materials
Raw materials3-(4-(3-methoxyphenoxy)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)aniline-->3-Aminobenzeneboronic acid
CHIR-99021 Tideglusib 2,6-PYRIDINEDIAMINE, N6-[2-[[4-(2,4-DICHLOROPHENYL)-5-(1H-IMIDAZOL-1-YL)-2-PYRIMIDINYL]AMINO]ETHYL]-3-NITRO- U0126-EtOH xav-939 IWR-1-endo GSK-3BETA INHIBITOR XII 1H-Pyrrolo[2,3-d]pyrimidine, 4-methoxy- (8CI,9CI)

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