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| | D-Proline Basic information |
| | D-Proline Chemical Properties |
| Melting point | 223 °C (dec.) (lit.) | | alpha | 84.75 º (c=4, H2O) | | Boiling point | 215.41°C (rough estimate) | | density | 1.36 | | refractive index | 85 ° (C=4, H2O) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Methanol (Slightly), Water (Sparingly) | | pka | 1.952(at 25℃) | | form | Powder | | color | White to yellow to pale brown | | optical activity | [α]22/D +85.0°, c = 4 in H2O | | Water Solubility | soluble >1000 g/L (20 ºC) | | Sensitive | Hygroscopic | | BRN | 80811 | | InChIKey | ONIBWKKTOPOVIA-SCSAIBSYSA-N | | LogP | -0.060 (est) | | CAS DataBase Reference | 344-25-2(CAS DataBase Reference) | | EPA Substance Registry System | D-Proline (344-25-2) |
| | D-Proline Usage And Synthesis |
| Chemical Properties | White to off-white powder | | Occurrence | D-proline is an isomer of the naturally occurring amino acid, L-Proline. D-amino acids have been found in relatively high abundance in human plasma and saliva. These amino acids may be of bacterial origin, but there is also evidence that they are endogenously produced through amino acid racemase activity. | | Uses | proline is a skin-conditioning agent. An amino acid found in the collagen molecule. | | Uses | Used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C. | | Uses | Labelled D-Proline
Lasubine II and (+)-Cermizine C. | | Definition | ChEBI: D-proline is the D-enantiomer of proline. It has a role as a mouse metabolite. It is a D-alpha-amino acid and a proline. It is a conjugate base of a D-prolinium. It is a conjugate acid of a D-prolinate. It is an enantiomer of a L-proline. It is a tautomer of a D-proline zwitterion. | | Synthesis Reference(s) | Journal of the American Chemical Society, 71, p. 2818, 1949 DOI: 10.1021/ja01176a065
Tetrahedron Letters, 28, p. 6469, 1987 DOI: 10.1016/S0040-4039(00)96890-4 |
| | D-Proline Preparation Products And Raw materials |
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