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| | Clomazone Basic information |
| | Clomazone Chemical Properties |
| Melting point | 25°C | | Boiling point | 275.4°C | | density | 1.192 | | refractive index | 1.5388 (estimate) | | Fp | 157 °C | | storage temp. | Sealed in dry,2-8°C | | solubility | DMF: 33 mg/ml,DMSO: 16 mg/ml,Ethanol: 33 mg/ml,PBS (pH 7.2): 1 mg/ml | | form | neat | | pka | -1.48±0.40(Predicted) | | Water Solubility | 1.101g/L(temperature not stated) | | BRN | 7480026 | | InChIKey | KIEDNEWSYUYDSN-UHFFFAOYSA-N | | CAS DataBase Reference | 81777-89-1(CAS DataBase Reference) | | NIST Chemistry Reference | Dimethazone(81777-89-1) | | EPA Substance Registry System | Clomazone (81777-89-1) |
| Hazard Codes | Xn | | Risk Statements | 20/22-36/38 | | Safety Statements | 26-36 | | RIDADR | 2902 | | WGK Germany | 2 | | RTECS | NY2977000 | | HazardClass | 6.1(b) | | PackingGroup | III | | Hazardous Substances Data | 81777-89-1(Hazardous Substances Data) | | Toxicity | LD50 in male rats, female rats, mallard duck-bobwhite quail (mg/kg): 2077, 1369, >2510 orally; in rabbits (mg/kg): >2000 dermally (Chen) |
| | Clomazone Usage And Synthesis |
| Description | The molecular target site of clomazone has recently
been determined. With clomazone, carotenoid synthesis
is inhibited, but no intermediates in the carotenoidcommitted
portion of the pathway accumulate (5,6).
Synthesis of the derivatives of GGPP (gibberellic acid,
phytol, carotenoids) is inhibited by clomazone (5–8).
However, the synthesis of certain sesquiterpenoids and
triterpenoids is not inhibited (9). Until recently, there was
no credible report of the effect of clomazone on any enzyme
of the terpenoid pathway (10–12). This was due to the
fact that clomazone is a proherbicide and that the proper
enzyme had not been tested. | | Chemical Properties | Depending purity, it may be clear and colorless to pale yellow or brownish liquid. Commercially available as emulsifiable concentrates that can be dissolved in water | | Uses | Herbicide. | | Definition | ChEBI: A oxazolidinone that is 1,2-oxazolidin-3-one substituted by a 2-chlorobenzyl group at position 2 and two methyl groups at position 4. | | Hazard | Moderately toxic by ingestion, inhalation,
and skin contact. A reproductive hazard. | | Agricultural Uses | Herbicide: Clomazone is a broad-spectrum herbicide used on
rice, peas, pumpkins, soybeans, sweet potatoes, winter
squash, cotton, tobacco and fallow wheat fields to control
annual grasses and broadleaf weeds. | | Trade name | CERANO®; COLZOR TRIO®;
COMMAND®; COMMENCE®, DIBEL®; FMC® 57020;
GAMBIT®; MAGISTER®; MERIT®; STRATEGY® | | Potential Exposure | Clomazone is a oxazolidione broadspectrum herbicide used on rice, peas, pumpkins, soybeans, sweet potatoes, winter squash, cotton, tobacco, and fallow wheat fields to control annual grasses and broadleaf weeds. | | Metabolic pathway | By the preparative incubation of clomazone with
microorganisms that have the ability to metabolize
clomazone, the metabolites are identified via major
biotransformation reactions which involve
hydroxylation at the 5-methylene carbon and one of
the 3-methyl groups of the isoxazolidone ring and at
the 3 0 -position of the phenyl ring. Minor metabolic
routes include dihydroxylation on the phenyl ring,
cleavage of the isoxazolinone ring, or complete
removal of the isoxazolinone ring to form
2-chlorobenzyl alcohol. Under aerobic conditions of
soils, degradation of clomazone proceeds primarily by
CO2 evolution and the formation of bound soil
residues. In flooded soils, clomazone is found rapidly
to degrade via the formation of the reductive product N-[(2-chlorophenyl)methyl]-3-hydroxy-2,2-
dimethylpropionamide. In tolerant soybean cell
suspension cultures, the only metabolite identified is
b-glycosyl-2-chlorobenzyl alcohol. | | Shipping | UN2902 Pesticide, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. | | Incompatibilities | Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. | | Waste Disposal | Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. |
| | Clomazone Preparation Products And Raw materials |
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