ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyran compounds 3-CYANO-7-ETHOXYCOUMARIN

3-CYANO-7-ETHOXYCOUMARIN

3-CYANO-7-ETHOXYCOUMARIN Basic information
Product Name:3-CYANO-7-ETHOXYCOUMARIN
Synonyms:7-Ethoxy-2-oxo-2H-chroMene-3-carbonitrile;7-ETHOXYCOUMARIN-3-CARBONITRILE;3-CYANO-7-ETHOXYCOUMARIN;2H-1-Benzopyran-3-carbonitrile,7-ethoxy-2-oxo-(9CI);7-Ethoxy-2-oxo-2H-1-benzopyran-3-carbonitrile;3-Cyano-7-ethoxycoumarin [7-Ethoxycoumarin-3-carbonitrile] *Cytochrome P450 Substrate*;CEC [3-Cyano-7-ethoxycoumarin] *CAS 117620-77-6*;CEC [3-Cyano-7-ethoxycoumarin
CAS:117620-77-6
MF:C12H9NO3
MW:215.2
EINECS:200-562-0
Product Categories:ETHOXY;Coumarins;Multi-Drug Resistance and Drug Metabolism;Drug and Xenobiotic Metabolism;Detection and Quantitation;Reagents;Substrates, Inducers, Inhibitors
Mol File:117620-77-6.mol
3-CYANO-7-ETHOXYCOUMARIN Structure
3-CYANO-7-ETHOXYCOUMARIN Chemical Properties
Melting point 210-212°C
Boiling point 396.8±42.0 °C(Predicted)
density 1.29±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble
form Solid
color yellow to orange
λmax356 nm (Buffer pH7); 355 nm(MeOH)
Biological ApplicationsAs a substrate for measuring cytochrome P450 enzymes activity; cytochrome P450 inhibition assays; drug design; drug metabolism; treating viral or parasite infections.
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
3-CYANO-7-ETHOXYCOUMARIN Usage And Synthesis
UsesSubstrate for determination of cytochrom P-450 dependent oxidases; about 50-100 times more sensitive than conventional substrate ethoxy-resorufin due to higher turn over rate.
Uses3-Cyano-7-ethoxycoumarin has been used as a substrate in cytochrome P (CYP) inhibition for fluorescence measurement.
General Description3-Cyano-7-ethoxycoumarin is a fluorescent substrate for Cytochrome P450 1A1 (CYP1A1), Cytochrome P450 1A2 (CYP1A2), Cytochrome P450 2C9 (CYP2C9) and Cytochrome P450 2C19 (CYP2C19).
Biochem/physiol ActionsFluorescent probe useful in microsomal dealkylase studies. Typical drug-drug interactions resulting from enzyme inhibition.
3-CYANO-7-ETHOXYCOUMARIN Preparation Products And Raw materials
Coumarin-3-carboxylic acid CoumarinDerivatives Sodium cyanoborohydride 7-METHOXY-2H-CHROMENE-3-CARBONITRILE 3-Cyano-7-hydroxycoumarin 4-METHOXYCINNAMONITRILE 3-CYANO-7-ETHOXYCOUMARIN 3-(3-methoxyphenoxy)propanenitrile 7-Ethoxycoumarin 3-CYANOCOUMARIN 2H-CHROMENE-3-CARBONITRILE
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